Lava Sebastiano A G, Bianchetti Mario G, Milani Gregorio P
Department of Pediatrics, University Children's Hospital of Bern, Inselspital, Bern, Switzerland; Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, Paris, France.
Pediatric Department of Southern Switzerland, Bellinzona, Switzerland; Università della Svizzera Italiana, Lugano, Switzerland.
Clin Kidney J. 2017 Apr;10(2):147-148. doi: 10.1093/ckj/sfw103. Epub 2016 Oct 13.
Both direct potentiometry and indirect potentiometry are currently used for Na testing in blood. These measurement techniques show good agreement as long as protein and lipid concentrations in blood remain normal. In severely ill patients, indirect potentiometry commonly leads to relevant errors in Na estimation: 25% of specimens show a disagreement between direct and indirect potentiometry, which is ≥4 mmol/L (mostly spuriously elevated Na level due to low circulating albumin concentration). There is a need for increased awareness of the poor performance of indirect potentiometry in some clinical settings.
目前，直接电位分析法和间接电位分析法都用于血液中钠的检测。只要血液中的蛋白质和脂质浓度保持正常，这些测量技术就显示出良好的一致性。在重症患者中，间接电位分析法通常会导致钠估计出现相关误差：25%的样本显示直接电位分析法和间接电位分析法之间的差异≥4 mmol/L（大多数情况下，由于循环白蛋白浓度低，钠水平假性升高）。在某些临床环境中，需要提高对间接电位分析法性能不佳的认识。
