Bomko Tatiana V, Nosalskaya Tatiana N, Kabluchko Tatiana V, Lisnyak Yury V, Martynov Artur V
Laboratory and Clinical Department of Molecular Immunopharmacology, Mechnikov Institute of Microbiology and Immunology, Kharkov, Ukraine.
J Pharm Pharmacol. 2017 Aug;69(8):1033-1040. doi: 10.1111/jphp.12726. Epub 2017 Apr 11.
Currently, probiotics are increasingly used as the alternative to antibiotics as well as the preventive measures in humans. In particular, probiotics occupy a key position in the treatment of antibiotics-associated intestinal dysbiosis. A spore-forming microorganism lactobacillus Bacillus coagulans is one of the most promising probiotics. However, some of its pharmacological effects remain poorly understood. This study was aimed at investigation of the effect of B. coagulans (Laktovit Forte) on the intestinal dysbiosis syndrome in mice caused by streptomycin against the background of cyclophosphamide-induced cellular immunodeficiency.
Pharmacological method: mouse model in vivo with immunodeficiency caused by cyclophosphamide.
In mice with colitis caused by streptomycin treatment, the administration of B. coagulans (Laktovit Forte medicinal product) resulted in an antidiarrhoeal effect, normalisation of gastrointestinal motility and prevention of the animals' weight loss. Given the cyclophosphamide-induced immunosuppression and streptomycin-associated diarrhoea, the immunity was completely restored only under the action of B. coagulans.
According to all parameters, B. coagulans has been proved to be more effective as compared to the Linex Forte reference product containing lacto- and bifidobacteria.
目前，益生菌越来越多地被用作抗生素的替代品以及人类的预防措施。特别是，益生菌在治疗抗生素相关性肠道菌群失调中占据关键地位。一种形成孢子的微生物凝结芽孢杆菌是最有前景的益生菌之一。然而，其一些药理作用仍了解甚少。本研究旨在探讨凝结芽孢杆菌（Laktovit Forte）在环磷酰胺诱导的细胞免疫缺陷背景下对链霉素所致小鼠肠道菌群失调综合征的影响。
药理学方法：采用环磷酰胺诱导免疫缺陷的小鼠体内模型。
在经链霉素治疗引起结肠炎的小鼠中，给予凝结芽孢杆菌（Laktovit Forte药用产品）产生了止泻作用，使胃肠动力恢复正常，并防止了动物体重减轻。考虑到环磷酰胺诱导的免疫抑制和链霉素相关腹泻，仅在凝结芽孢杆菌的作用下免疫力才完全恢复。
根据所有参数，已证明凝结芽孢杆菌比含有乳酸菌和双歧杆菌的对照产品Linex Forte更有效。
