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本文引用的文献

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Expressions of the CagA protein and CagA-signaling molecules predict Helicobacter pylori dependence of early-stage gastric DLBCL.CagA 蛋白和 CagA 信号分子的表达预测了早期胃弥漫性大 B 细胞淋巴瘤对幽门螺杆菌的依赖性。
Blood. 2017 Jan 12;129(2):188-198. doi: 10.1182/blood-2016-04-713719. Epub 2016 Nov 18.
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Helicobacter pylori Diversity and Gastric Cancer Risk.幽门螺杆菌的多样性与胃癌风险
mBio. 2016 Jan 26;7(1):e01869-15. doi: 10.1128/mBio.01869-15.
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Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion.幽门螺杆菌 cagA 启动子区序列影响 CagA 表达和白细胞介素 8 分泌。
J Infect Dis. 2016 Feb 15;213(4):669-73. doi: 10.1093/infdis/jiv467. Epub 2015 Sep 23.
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Dormant phages of Helicobacter pylori reveal distinct populations in Europe.幽门螺杆菌的潜伏噬菌体揭示了欧洲不同的种群。
Sci Rep. 2015 Sep 21;5:14333. doi: 10.1038/srep14333.
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Genome Sequences of Three Helicobacter pylori Strains from Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma.来自胃黏膜相关淋巴组织淋巴瘤患者的三株幽门螺杆菌菌株的基因组序列
Genome Announc. 2015 Apr 23;3(2):e00229-15. doi: 10.1128/genomeA.00229-15.
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Helicobacter pylori CagA Translocation Is Closely Associated With the Expression of CagA-signaling Molecules in Low-grade Gastric Mucosa-associated Lymphoid Tissue Lymphoma.幽门螺杆菌 CagA 易位与低级别胃黏膜相关淋巴组织淋巴瘤中 CagA 信号分子的表达密切相关。
Am J Surg Pathol. 2015 Jun;39(6):761-6. doi: 10.1097/PAS.0000000000000437.
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The Role of Helicobacter pylori Outer Membrane Proteins in Adherence and Pathogenesis.幽门螺杆菌外膜蛋白在黏附和发病机制中的作用。
Biology (Basel). 2013 Aug 27;2(3):1110-34. doi: 10.3390/biology2031110.
8
Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas.幽门螺杆菌在胃黏膜相关淋巴组织淋巴瘤中的作用。
World J Gastroenterol. 2014 Jan 21;20(3):684-98. doi: 10.3748/wjg.v20.i3.684.
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Gastric marginal zone lymphoma of MALT type: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.胃MALT型边缘区淋巴瘤：ESMO诊断、治疗及随访临床实践指南
Ann Oncol. 2013 Oct;24 Suppl 6:vi144-8. doi: 10.1093/annonc/mdt343.
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Detection of the Helicobacter pylori CagA protein in gastric mucosa-associated lymphoid tissue lymphoma cells: clinical and biological significance.检测胃黏膜相关淋巴组织淋巴瘤细胞中的幽门螺杆菌 CagA 蛋白：临床和生物学意义。
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幽门螺杆菌菌株与胃黏膜相关淋巴组织淋巴瘤

Helicobacter pylori Strains and Gastric MALT Lymphoma.

作者信息

Floch Pauline, Mégraud Francis, Lehours Philippe

机构信息

INSERM, Univ. Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France.

出版信息

Toxins (Basel). 2017 Apr 8;9(4):132. doi: 10.3390/toxins9040132.

DOI:10.3390/toxins9040132
PMID:28397767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5408206/
Abstract

This article summarizes the main findings concerning associated with gastric MALT lymphoma (GML). Considered together, GML strains based on their virulence factor profile appear to be less virulent than those associated with peptic ulcers or gastric adenocarcinoma. A particular Lewis antigen profile has been identified in GML strains and could represent an alternative adaptive mechanism to escape the host immune response thereby allowing continuous antigenic stimulation of infiltrating lymphocytes.

摘要

本文总结了与胃黏膜相关淋巴组织淋巴瘤（GML）相关的主要研究结果。综合来看，基于其毒力因子谱的GML菌株似乎比与消化性溃疡或胃腺癌相关的菌株毒力更低。在GML菌株中已鉴定出一种特定的Lewis抗原谱，它可能代表一种逃避宿主免疫反应的替代适应性机制，从而使浸润淋巴细胞能够持续受到抗原刺激。