幽门螺杆菌菌株与胃黏膜相关淋巴组织淋巴瘤
Helicobacter pylori Strains and Gastric MALT Lymphoma.
作者信息
Floch Pauline, Mégraud Francis, Lehours Philippe
机构信息
INSERM, Univ. Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France.
出版信息
Toxins (Basel). 2017 Apr 8;9(4):132. doi: 10.3390/toxins9040132.
Abstract
This article summarizes the main findings concerning associated with gastric MALT lymphoma (GML). Considered together, GML strains based on their virulence factor profile appear to be less virulent than those associated with peptic ulcers or gastric adenocarcinoma. A particular Lewis antigen profile has been identified in GML strains and could represent an alternative adaptive mechanism to escape the host immune response thereby allowing continuous antigenic stimulation of infiltrating lymphocytes.
摘要
本文总结了与胃黏膜相关淋巴组织淋巴瘤（GML）相关的主要研究结果。综合来看，基于其毒力因子谱的GML菌株似乎比与消化性溃疡或胃腺癌相关的菌株毒力更低。在GML菌株中已鉴定出一种特定的Lewis抗原谱，它可能代表一种逃避宿主免疫反应的替代适应性机制，从而使浸润淋巴细胞能够持续受到抗原刺激。
相似文献
1
Helicobacter pylori Strains and Gastric MALT Lymphoma.
Toxins (Basel). 2017 Apr 8;9(4):132. doi: 10.3390/toxins9040132.
2
Role of Helicobacter pylori virulence factor cytotoxin-associated gene A in gastric mucosa-associated lymphoid tissue lymphoma.
World J Gastroenterol. 2013 Dec 7;19(45):8219-26. doi: 10.3748/wjg.v19.i45.8219.
3
[Helicobacter pylori and gastric cancer].
Rev Gastroenterol Peru. 2008 Jul-Sep;28(3):258-66.
4
[Helicobacter pylori. I. Morphology, biochemistry, antigenic profile and correlated diseases].
Pediatr Med Chir. 1998 Sep-Oct;20(5):323-8.
5
Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review.
World J Gastroenterol. 2015 Jul 14;21(26):8014-20. doi: 10.3748/wjg.v21.i26.8014.
6
CagA+ H. pylori strains and gastric lymphoma.
Gastroenterology. 1997 Dec;113(6):2022-3.
7
Helicobacter pylori virulence factors in gastric carcinogenesis.
Cancer Lett. 2009 Sep 8;282(1):1-8. doi: 10.1016/j.canlet.2008.11.016. Epub 2008 Dec 25.
8
Gastric MALT lymphoma and Helicobacter pylori.
Cancer Surv. 1997;30:213-31.
9
Evaluation of the association of nine Helicobacter pylori virulence factors with strains involved in low-grade gastric mucosa-associated lymphoid tissue lymphoma.
Infect Immun. 2004 Feb;72(2):880-8. doi: 10.1128/IAI.72.2.880-888.2004.
10
Helicobacter pylori infection and gastric cancer.
Med Electron Microsc. 2004 Sep;37(3):149-57. doi: 10.1007/s00795-004-0250-7.
引用本文的文献
1
First regional consensus on the management of infection in the Middle East.
World J Gastroenterol. 2025 Jul 21;31(27):107138. doi: 10.3748/wjg.v31.i27.107138.
2
A Reverse Vaccinology and Immunoinformatic Approach for the Designing of a Novel mRNA Vaccine Against Stomach Cancer Targeting the Potent Pathogenic Proteins of .
Bioinform Biol Insights. 2025 Apr 16;19:11779322251331104. doi: 10.1177/11779322251331104. eCollection 2025.
3
Overcoming antibiotic-resistant infection: Current challenges and emerging approaches.
World J Gastroenterol. 2025 Mar 14;31(10):102289. doi: 10.3748/wjg.v31.i10.102289.
4
Cholesterol Functionalized Nanoparticles Are Effective against Helicobacter pylori, the Gastric Bug: A Proof-of-Concept Study.
Adv Healthc Mater. 2025 Apr;14(10):e2404065. doi: 10.1002/adhm.202404065. Epub 2025 Feb 5.
5
Cooperative participation of CagA and NFATc1 in the pathogenesis of antibiotics-responsive gastric MALT lymphoma.
Cancer Cell Int. 2024 Nov 18;24(1):383. doi: 10.1186/s12935-024-03552-6.
6
The Influence of the Microbiome on the Complications of Radiotherapy and Its Effectiveness in Patients with Laryngeal Cancer.
Cancers (Basel). 2024 Nov 1;16(21):3707. doi: 10.3390/cancers16213707.
7
Analysis of Risk Factors with Assessment of the Impact of the Microbiome on the Risk of Squamous Cell Carcinoma of the Larynx.
J Clin Med. 2024 Oct 13;13(20):6101. doi: 10.3390/jcm13206101.
8
Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies.
Cancer Metastasis Rev. 2024 Dec;43(4):1315-1336. doi: 10.1007/s10555-024-10197-4. Epub 2024 Jul 15.
9
Machine Learning-Driven Classification of Urease Inhibitors Leveraging Physicochemical Properties as Effective Filter Criteria.
Int J Mol Sci. 2024 Apr 13;25(8):4303. doi: 10.3390/ijms25084303.
10
A Mini-review on with Gastric Cancer and Available Treatments.
Endocr Metab Immune Disord Drug Targets. 2024;24(3):277-290. doi: 10.2174/1871530323666230824161901.
本文引用的文献
1
Expressions of the CagA protein and CagA-signaling molecules predict Helicobacter pylori dependence of early-stage gastric DLBCL.
Blood. 2017 Jan 12;129(2):188-198. doi: 10.1182/blood-2016-04-713719. Epub 2016 Nov 18.
2
Helicobacter pylori Diversity and Gastric Cancer Risk.
mBio. 2016 Jan 26;7(1):e01869-15. doi: 10.1128/mBio.01869-15.
3
Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion.
J Infect Dis. 2016 Feb 15;213(4):669-73. doi: 10.1093/infdis/jiv467. Epub 2015 Sep 23.
4
Dormant phages of Helicobacter pylori reveal distinct populations in Europe.
Sci Rep. 2015 Sep 21;5:14333. doi: 10.1038/srep14333.
5
Genome Sequences of Three Helicobacter pylori Strains from Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma.
Genome Announc. 2015 Apr 23;3(2):e00229-15. doi: 10.1128/genomeA.00229-15.
6
Helicobacter pylori CagA Translocation Is Closely Associated With the Expression of CagA-signaling Molecules in Low-grade Gastric Mucosa-associated Lymphoid Tissue Lymphoma.
Am J Surg Pathol. 2015 Jun;39(6):761-6. doi: 10.1097/PAS.0000000000000437.
7
The Role of Helicobacter pylori Outer Membrane Proteins in Adherence and Pathogenesis.
Biology (Basel). 2013 Aug 27;2(3):1110-34. doi: 10.3390/biology2031110.
8
Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas.
World J Gastroenterol. 2014 Jan 21;20(3):684-98. doi: 10.3748/wjg.v20.i3.684.
9
Gastric marginal zone lymphoma of MALT type: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Ann Oncol. 2013 Oct;24 Suppl 6:vi144-8. doi: 10.1093/annonc/mdt343.
10
Detection of the Helicobacter pylori CagA protein in gastric mucosa-associated lymphoid tissue lymphoma cells: clinical and biological significance.
Blood Cancer J. 2013 Jul 12;3(7):e125. doi: 10.1038/bcj.2013.22.
Zotero 插件