Respiratory Division, Department of Clinical and Experimental Medicine, University Hospitals Leuven, KU Leuven, Belgium.
Thorax. 2018 Feb;73(2):188-190. doi: 10.1136/thoraxjnl-2016-209746. Epub 2017 Apr 14.
: Probe-based confocal laser endomicroscopy (pCLE) was performed in 15 patients with emphysema and 15 healthy subjects to visualise small airways in a direct and dynamic way. Morphometry shows that the median cross-sectional area of the alveolar openings at the level of the alveolar ducts is significantly larger in emphysema (7.2×10 µm) as compared with healthy subjects (5.2×10 µm) (p=0.0002). Normalised autofluorescence intensity histograms show a decrease in median autofluorescence intensity (mAFI) in emphysema (p=0.001). mAFI correlates well with Tiffeneau index (r=0.66, p=0.007, 95% CI 0.21 to 0.88). Autofluorescence intensity in emphysema correlates with corresponding data of CT-based quantification. pCLE-based morphometry and autofluorescence intensity analysis in emphysema is able to detect regional changes inside the 'quiet zone'.
Results, NCT01204970.
研究人员在 15 例肺气肿患者和 15 例健康受试者中进行了基于探头的共聚焦激光内窥镜检查（pCLE），以直接和动态的方式观察小气道。形态计量学显示，在肺泡管水平，肺泡开口的中截面面积在肺气肿患者中明显更大（7.2×10 µm），而在健康受试者中则较小（5.2×10 µm）（p=0.0002）。正常化的自体荧光强度直方图显示，肺气肿患者的中位自体荧光强度（mAFI）降低（p=0.001）。mAFI 与 Tiffeneau 指数相关性良好（r=0.66，p=0.007，95%CI 0.21 至 0.88）。肺气肿中的自体荧光强度与基于 CT 的定量相应数据相关。肺气肿中基于 pCLE 的形态计量学和自体荧光强度分析能够检测到“安静区”内的区域变化。
试验结果，NCT01204970。
