Le Moyec Laurence, Triba Mohamed N, Nahon Pierre, Bouchemal Nadia, Hantz Edith, Goossens Corentine, Amathieu Roland, Savarin Philippe
Unit of Integrative Biology for Exercise Adaptation (UBIAE), University of Evry Val d'Essonne, EA 7362, F-91025 Evry, France.
University of Paris 13, Sorbonne Paris Cité, CSPBAT Laboratory, UMR 7244, CNRS, F-93000 Bobigny, France.
Biomed Rep. 2017 Apr;6(4):387-395. doi: 10.3892/br.2017.868. Epub 2017 Mar 3.
During the last decade, metabolomics has become widely used in the field of human diseases. Numerous studies have demonstrated that this is a powerful technique for improving the understanding, diagnosis and management of various types of liver disease, such as acute and chronic liver diseases, and liver transplantation. Nuclear magnetic resonance (NMR) spectroscopy is one of the two most commonly applied methods for metabolomics. The aim of the present review was to investigate the results from recent key publications focusing on aspects of protein and carbohydrate metabolism. The review includes existing procedures, which are currently used for NMR data acquisition and statistical analysis. In addition, notable results obtained by these studies on protein and carbohydrate metabolism concerning human liver diseases are presented.
在过去十年中，代谢组学已在人类疾病领域得到广泛应用。大量研究表明，这是一种强大的技术，有助于增进对各类肝病（如急慢性肝病和肝移植）的理解、诊断和管理。核磁共振（NMR）光谱法是代谢组学最常用的两种方法之一。本综述的目的是研究近期重点关注蛋白质和碳水化合物代谢方面的关键出版物的结果。该综述包括目前用于NMR数据采集和统计分析的现有程序。此外，还介绍了这些关于人类肝病的蛋白质和碳水化合物代谢研究取得的显著成果。
