Tanik Serhat, Zengin Kürsad, Albayrak Sebahattin, Gurel Abdullah, Atar Muhittin, Sahin Sevinc, Tuzcu Nevin, Tuzcu Mehmet, Imamoglu Muhammet Abdurrahim, Gurdal Mesut
Department of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
Department of Urology, Afyon Kocatepe University, School of Medicine, Afyon, Turkey.
Kaohsiung J Med Sci. 2017 May;33(5):229-235. doi: 10.1016/j.kjms.2017.02.003. Epub 2017 Mar 27.
In this study, female rats induced with chemical cystitis were administered the hormone human choriogonadotropin (HCG), and it was aimed to reveal the usefulness of HCG in the treatment of interstitial cystitis/bladder pain syndrome. The materials for this study were 32 Wistar albino female rats. The study groups were formed as follows: the cystitis group (Group 1), the cystitis + HCG protection group (Group 2), the cystitis + HCG treatment group (Group 3), and the control group (Group 4), with eight rats in each group. In this study, blood and urine samples were taken from the rats, they were euthanized, and their bladders were removed for glutathione, malondialdehyde, tumor necrosis factor alpha, and interferon gamma measurements. It was observed that tissue damage in Group 2 was lower than that in the other two groups. Glutathione levels in Groups 2 and 4 were significantly higher than in Groups 1 and 3 (p = 0.01). Malondialdehyde levels of Groups 2 and 4 were significantly lower than the values in Groups 1 and 3 (p < 0.001). When the cystitis groups were compared in terms of their interferon gamma and tumor necrosis factor alpha levels, the lowest interferon gamma and tumor necrosis factor alpha levels were detected in Group 3. It was found that HCG has positive effects on experimental cystitis in rats. This study revealed that HCG should be researched as a therapeutic agent and formed a step for studies to be carried out on this subject.
在本研究中，对诱导化学性膀胱炎的雌性大鼠给予人绒毛膜促性腺激素（HCG），旨在揭示HCG在治疗间质性膀胱炎/膀胱疼痛综合征中的效用。本研究的材料为32只Wistar白化雌性大鼠。研究组分组如下：膀胱炎组（第1组）、膀胱炎+HCG保护组（第2组）、膀胱炎+HCG治疗组（第3组）和对照组（第4组），每组8只大鼠。在本研究中，从大鼠采集血液和尿液样本，将其安乐死，并取出膀胱用于测量谷胱甘肽、丙二醛、肿瘤坏死因子α和干扰素γ。观察到第2组的组织损伤低于其他两组。第2组和第4组的谷胱甘肽水平显著高于第1组和第3组（p = 0.01）。第2组和第4组的丙二醛水平显著低于第1组和第3组的值（p < 0.001）。当比较膀胱炎组的干扰素γ和肿瘤坏死因子α水平时，第3组检测到最低的干扰素γ和肿瘤坏死因子α水平。发现HCG对大鼠实验性膀胱炎有积极作用。本研究表明，应将HCG作为一种治疗剂进行研究，并为在该主题上开展的研究迈出了一步。
