Valstad Mathias, Alvares Gail A, Egknud Maiken, Matziorinis Anna Maria, Andreassen Ole A, Westlye Lars T, Quintana Daniel S
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway.
Telethon Kids Institute, University of Western Australia, Australia; Cooperative Research Centre for Living with Autism (Autism CRC), Long Pocket, Brisbane, Australia.
Neurosci Biobehav Rev. 2017 Jul;78:117-124. doi: 10.1016/j.neubiorev.2017.04.017. Epub 2017 Apr 23.
There is growing interest in the role of the oxytocin system in social cognition and behavior. Peripheral oxytocin concentrations are regularly used to approximate central concentrations in psychiatric research, however, the validity of this approach is unclear. Here we conducted a pre-registered systematic search and meta-analysis of correlations between central and peripheral oxytocin concentrations. A search of databases yielded 17 eligible studies, resulting in a total sample size of 516 participants and subjects. Overall, a positive association between central and peripheral oxytocin concentrations was revealed [r=0.29, 95% CI (0.14, 0.42), p<0.0001]. This association was moderated by experimental context [Q(4), p=0.003]. While no association was observed under basal conditions (r=0.08, p=0.31), significant associations were observed after intranasal oxytocin administration (r=0.66, p<0.0001), and after experimentally induced stress (r=0.49, p=0.001). These results indicate a coordination of central and peripheral oxytocin release after stress and after intranasal administration. Although popular, the approach of using peripheral oxytocin levels to approximate central levels under basal conditions is not supported by the present results.
催产素系统在社会认知和行为中的作用正受到越来越多的关注。在精神病学研究中，外周催产素浓度常被用来近似中枢浓度，然而，这种方法的有效性尚不清楚。在此，我们对中枢和外周催产素浓度之间的相关性进行了预先注册的系统检索和荟萃分析。对数据库的检索产生了17项符合条件的研究，样本总量为516名参与者和受试者。总体而言，中枢和外周催产素浓度之间呈现正相关[r = 0.29，95%CI(0.14, 0.42)，p < 0.0001]。这种相关性受实验背景调节[Q(4)，p = 0.003]。在基础条件下未观察到相关性(r = 0.08，p = 0.31)，但在鼻内给予催产素后(r = 0.66，p < 0.0001)以及在实验诱导的应激后(r = 0.49，p = 0.001)观察到显著相关性。这些结果表明，在应激和鼻内给药后，中枢和外周催产素释放存在协调关系。尽管外周催产素水平在基础条件下用于近似中枢水平的方法很常用，但目前的结果并不支持这一方法。
