School of Life Science, Dentistry Department, Graduate Program of Dentistry, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Caries Res. 2017;51(3):240-243. doi: 10.1159/000464450. Epub 2017 Apr 27.
The objective of this research was to identify and replicate the participation of KLK4 gene polymorphisms in the susceptibility to dental decay.
A total of 200 patients were recruited using ICDAS criteria - 100 of them with dental caries and 100 with no history of the disease. Buccal cells were collected and the DNA was extracted and amplified using PCR.
During the descriptive analysis, the variables ethnicity, biofilm, and gingivitis and the markers rs2242670 and rs2978642 were statistically significant. In the multivariate analysis, the marker rs2242670 and the variable biofilm maintained statistical significance.
Genetic variations in the KLK4 gene may contribute to dental decay.
本研究旨在鉴定并复制 KLK4 基因多态性在龋齿易感性中的作用。
采用 ICDAS 标准纳入 200 例患者，其中 100 例患有龋齿，100 例无龋齿病史。采集颊黏膜细胞，提取 DNA 后采用 PCR 进行扩增。
在描述性分析中，种族、生物膜、牙龈炎和标记物 rs2242670、rs2978642 具有统计学意义。在多变量分析中，标记物 rs2242670 和生物膜变量仍具有统计学意义。
KLK4 基因的遗传变异可能导致龋齿。
