Hierholzer J C, Wigand R, Anderson L J, Adrian T, Gold J W
Respiratory and Enteric Viruses Branch, Centers for Disease Control, Atlanta, Georgia 30333.
J Infect Dis. 1988 Oct;158(4):804-13. doi: 10.1093/infdis/158.4.804.
We analyzed 67 adenovirus isolates from 48 patients with AIDS. The isolates included 5 of subgenus A (all Ad31), 23 of subgenus B, 4 of subgenus C (all Ad5), and 35 of subgenus D. The subgenus A and C strains were from liver, lung, blood, urine, and stool and were unremarkable in their antigenic characteristics. The subgenus B strains were mostly from urine and were serotyped by neutralization (SN) and hemagglutination-inhibition (HAI) tests as Ad11 (12 isolates), Ad16 (1), Ad35 (3), and Ad21/H21 + 35 (1) plus new intermediate strains 34/H11 (3), 35/H11 (1), and 11 + 35/H11 (2). The subgenus D serotypes from 24 patients were mostly from stool specimens and consisted of 8 isolates of known serotypes, 16 of antigenically intermediate strains, and 11 of five new adenovirus types with distinct antigenic and restriction enzyme characteristics. The new serotypes were described as candidate types 43-47 in accordance with currently accepted taxonomic criteria. Ad45, 46, and 47 showed a major relation by HAI with Ad29, 24, and 20, respectively. Four intermediate types were related to the new serotypes. The plethora of serotypes from patients with AIDS suggests that no epidemiological significance can be attached to any one serotype.
我们分析了来自48例艾滋病患者的67株腺病毒分离株。这些分离株包括5株A亚属（均为Ad31）、23株B亚属、4株C亚属（均为Ad5）和35株D亚属。A亚属和C亚属毒株来自肝脏、肺、血液、尿液和粪便，其抗原特性无明显异常。B亚属毒株大多来自尿液，通过中和试验（SN）和血凝抑制试验（HAI）鉴定为Ad11（12株）、Ad16（1株）、Ad35（3株）和Ad21/H21 + 35（1株），外加新的中间株34/H11（3株）、35/H11（1株）和11 + 35/H11（2株）。来自24例患者的D亚属血清型大多来自粪便标本，包括8株已知血清型分离株、16株抗原性中间株和11株具有独特抗原和限制性内切酶特征的5种新型腺病毒。根据目前公认的分类标准，这些新血清型被描述为候选型43 - 47。Ad45、46和47在HAI试验中分别与Ad29、24和20有主要关联。4种中间型与新血清型相关。艾滋病患者中血清型众多表明任何一种血清型都没有流行病学意义。
