Jacobs Delphine, Willekens Diane, de Die-Smulders Christine, Frijns Jean-Pierre, Steyaert Jean
Centre for Human Genetics, University of Leuven, Leuven, Belgium.
Department of Clinical Genetics, Academic Hospital Maastricht, Maastricht, The Netherlands.
Am J Med Genet B Neuropsychiatr Genet. 2017 Jun;174(4):359-366. doi: 10.1002/ajmg.b.32524. Epub 2017 Apr 27.
We investigated the clinically derived hypothesis of a relatively high incidence of delusional and psychotic disorders in adolescents with juvenile Myotonic Dystrophy type-1 (DM1). Twenty-seven subjects of age 16-25 with juvenile DM1 and their parents were invited to have a clinical psychiatric interview, and to complete an ASEBA behavior checklist (YSR, ASR, CBCL, and ABCL). We diagnosed a Delusional Disorder in 19% of our patients and a Psychotic Disorder not otherwise specified in another 19%. These two groups of patients had a significantly worse level of clinically defined general functioning. It is clinically relevant to investigate in patients with juvenile DM the symptom of delusions and the presence of a delusional and psychotic disorder, and to consider the presence of juvenile DM in youngsters presenting with such a thought disorder. These disorders compromise the general functioning of the subjects and are often to some extent treatable. © 2017 Wiley Periodicals, Inc.
我们对一个临床上得出的假说进行了研究，该假说认为患有青少年1型强直性肌营养不良（DM1）的青少年中，妄想症和精神障碍的发病率相对较高。邀请了27名年龄在16至25岁之间的青少年DM1患者及其父母进行临床精神科访谈，并完成一份ASEBA行为清单（YSR、ASR、CBCL和ABCL）。我们诊断出19%的患者患有妄想症，另有19%的患者患有未另行指定的精神障碍。这两组患者在临床定义的总体功能水平上明显更差。对患有青少年DM的患者调查妄想症状以及妄想症和精神障碍的存在情况，并考虑在出现此类思维障碍的青少年中是否存在青少年DM，这在临床上具有相关性。这些障碍会损害受试者的总体功能，并且在某种程度上通常是可治疗的。© 2017威利期刊公司
