Yan Xiaoting, Tong Zongrui, Chen Yu, Mo Yanghe, Feng Huaiyu, Li Peng, Qu Xiaosai, Jin Shaohua
School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
Mar Drugs. 2017 Apr 28;15(5):127. doi: 10.3390/md15050127.
Carboxymethyl chitosan (CMCS) microparticles are a potential candidate for hemostatic wound dressing. However, its low swelling property limits its hemostatic performance. Poly(γ-glutamic acid) (PGA) is a natural polymer with excellent hydrophilicity. In the current study, a novel CMCS/PGA composite microparticles with a dual-network structure was prepared by the emulsification/internal gelation method. The structure and thermal stability of the composite were determined by Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). The effects of preparation conditions on the swelling behavior of the composite were investigated. The results indicate that the swelling property of CMCS/PGA composite microparticles is pH sensitive. Levofloxacin (LFX) was immobilized in the composite microparticles as a model drug to evaluate the drug delivery performance of the composite. The release kinetics of LFX from the composite microparticles with different structures was determined. The results suggest that the CMCS/PGA composite microparticles are an excellent candidate carrier for drug delivery.
羧甲基壳聚糖（CMCS）微粒是一种有潜力的止血伤口敷料候选材料。然而，其低溶胀性能限制了其止血性能。聚（γ-谷氨酸）（PGA）是一种具有优异亲水性的天然聚合物。在本研究中，通过乳化/内部凝胶法制备了一种具有双网络结构的新型CMCS/PGA复合微粒。采用傅里叶变换红外光谱（FTIR）、X射线粉末衍射（XRD）、扫描电子显微镜（SEM）、X射线光电子能谱（XPS）和热重分析（TGA）对复合材料的结构和热稳定性进行了测定。研究了制备条件对复合材料溶胀行为的影响。结果表明，CMCS/PGA复合微粒的溶胀性能对pH敏感。将左氧氟沙星（LFX）作为模型药物固定在复合微粒中，以评估复合材料的药物递送性能。测定了不同结构的复合微粒中LFX的释放动力学。结果表明，CMCS/PGA复合微粒是一种优异的药物递送候选载体。
