Aasvik Julie, Stiles Tore C, Woodhouse Astrid, Borchgrevink Petter, Inge Landrø Nils
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Hysnes Rehabilitation Center, St. Olav's University Hospital, Trondheim, Norway.
Arch Clin Neuropsychol. 2018 Feb 1;33(1):14-23. doi: 10.1093/arclin/acx040.
To examine if elevated symptoms of insomnia affects neuropsychological functioning in patients with concurrent symptoms of pain, fatigue, and mood disorders.
A total of seventy-six subjects participated in this (cross-sectional) study. Based on the cut-off score guidelines from The Insomnia Severity Index subjects were assigned to either a clinical insomnia group (N = 35) or a comparison group (N = 41). Factors such as age, general cognitive functioning, and symptoms of pain, fatigue, depression, and anxiety did not differ between the groups. Both groups completed a questionnaire which assessed subjective memory functioning. In addition they completed a set of neuropsychological tests measuring general cognitive functioning, spatial and verbal working memory, and inhibitory control. Although the subjects with clinical insomnia did not report more memory problems than the comparison group, they presented significant deficiencies on the tests assessing spatial and verbal working memory. There was no difference between the groups in inhibitory control.
This study shows that as the symptom severity of insomnia increases and become clinically significant, it has substantial effect on both spatial and verbal-numeric working memory functioning. By differentiating and testing different domains of working memory, this study provides a more detailed and nuanced characterization of working memory deficiencies than the previous studies within this field. The results need to be transferred to clinical practice so that neuropsychologists include assessments of sleep as part of their routine screenings.
研究失眠症状加重是否会影响同时伴有疼痛、疲劳和情绪障碍症状的患者的神经心理功能。
共有76名受试者参与了这项（横断面）研究。根据失眠严重程度指数的临界值标准，受试者被分为临床失眠组（N = 35）或对照组（N = 41）。两组在年龄、一般认知功能以及疼痛、疲劳、抑郁和焦虑症状等因素上没有差异。两组都完成了一份评估主观记忆功能的问卷。此外，他们还完成了一组神经心理测试，测量一般认知功能、空间和言语工作记忆以及抑制控制。虽然临床失眠组的受试者报告的记忆问题并不比对照组多，但他们在评估空间和言语工作记忆的测试中表现出明显不足。两组在抑制控制方面没有差异。
本研究表明，随着失眠症状严重程度增加并达到临床显著水平，它对空间和言语数字工作记忆功能都有实质性影响。通过区分和测试工作记忆的不同领域，本研究比该领域以前的研究提供了更详细、更细微的工作记忆缺陷特征。这些结果需要应用到临床实践中，以便神经心理学家将睡眠评估纳入他们的常规筛查中。
