Department of Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway.
Department of Health Sciences, Institute of Health and Society, University of Oslo, Oslo, Norway.
Br J Sports Med. 2017 Jul;51(14):1065-1072. doi: 10.1136/bjsports-2016-097149. Epub 2017 Apr 28.
To investigate the effects of cardiorespiratory and strength exercises on disease activity for patients with inflammatory rheumatic diseases (IRDs).
A systematic review with meta-analysis registered at PROSPERO (CRD42015020004).
Patients with IRDs.
The databases MEDLINE, AMED, Embase and CINAHL were searched from inception up to April 2016.
Trials were included if they were randomised controlled trials of adults with IRDs, comparing the effect of cardiorespiratory and strength exercises with usual care on disease activity and followed the American College of Sports Medicine's exercise recommendations. The primary outcome was disease activity in terms of inflammation, joint damage and symptoms.
Data were pooled in a random-effect model for all outcomes, and standardised mean differences (SMDs) were calculated. The quality of evidence was evaluated according to the Grading of Recommendations Assessment, Development and Evaluation approach.
Twenty-six trials with a total of 1286 participants were included. There was high to moderate quality evidence, for a small beneficial effect on disease activity scores (0.19 (95% CI 0.05 to 0.33), p<0.01) and joint damage (SMD 0.27 (95% CI 0.07 to 0.46), p<0.01). Furthermore, moderate quality evidence for a small beneficial effect on erythrocyte sedimentation rate (SMD 0.20 (95% CI 0.0 to 0.39), p=0.04) and for no effect on C reactive protein (SMD -0.14 (95% CI -0.37 to 0.08), p=0.21). Beneficial effects were also seen for symptoms.
The results of this review suggest beneficial effects of exercises on inflammation, joint damage and symptoms in patients with IRDs.
研究心肺功能锻炼和力量训练对炎症性风湿病（IRDs）患者疾病活动的影响。
系统评价和荟萃分析，在 PROSPERO（CRD42015020004）注册。
IRDs 患者。
从建库到 2016 年 4 月，检索 MEDLINE、AMED、Embase 和 CINAHL 数据库。
试验为成人 IRDs 患者的随机对照试验，比较心肺功能锻炼和力量训练与常规护理对疾病活动的影响，并遵循美国运动医学学院的运动建议。主要结局为炎症、关节损伤和症状方面的疾病活动。
所有结局均采用随机效应模型进行数据汇总，并计算标准化均数差（SMD）。证据质量根据推荐评估、制定与评估分级方法进行评估。
纳入 26 项试验，共 1286 名参与者。证据质量为高到中等，显示疾病活动评分（0.19[95%CI 0.05 至 0.33]，p<0.01）和关节损伤（SMD 0.27[95%CI 0.07 至 0.46]，p<0.01）有小的有益效应。此外，红细胞沉降率（SMD 0.20[95%CI 0.0 至 0.39]，p=0.04）有中等质量证据显示有小的有益效应，C 反应蛋白（SMD-0.14[95%CI-0.37 至 0.08]，p=0.21）无效应。症状也有有益效应。
本综述结果提示，锻炼对 IRDs 患者的炎症、关节损伤和症状有有益影响。
