State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Molecules. 2021 Jul 10;26(14):4201. doi: 10.3390/molecules26144201.
As a traditional Chinese medicine, Link has been used to treat various inflammatory-related diseases, and recent studies have shown that it possesses potent anti-inflammatory activity. Therefore, phytochemical investigation on whole plants of were carried out, which led to the isolation of two new iridoid glucosides, patriniscabiosides A () and B (), together with six known compounds (-). The structural elucidation of all compounds was performed by HRESIMS and extensive spectroscopic analyses including IR, 1D, 2D NMR, and electronic circular dichroism (ECD). All the isolated compounds were tested for their anti-inflammatory activity using the NF-κB-Dependent Reporter Gene Expression Assay, and compound displayed anti-inflammatory activity through the inhibition of the NF-κB pathway, with an inhibitory rate of 73.44% at a concentration of 10 μM.
作为一种传统中药，贯叶金丝桃已被用于治疗各种炎症相关疾病，最近的研究表明其具有很强的抗炎活性。因此，对贯叶金丝桃全草进行了植物化学研究，从中分离得到了两个新的环烯醚萜葡萄糖苷，即贯叶连翘苷 A（）和 B（），以及六个已知化合物（-）。所有化合物的结构均通过高分辨质谱和包括 IR、1D、2D NMR 和电子圆二色性（ECD）在内的广泛光谱分析进行了阐明。所有分离得到的化合物均通过 NF-κB 依赖性报告基因表达测定进行了抗炎活性测试，化合物 显示出通过抑制 NF-κB 通路的抗炎活性，在 10 μM 浓度下的抑制率为 73.44%。
