宏量营养素与下丘脑FTO基因表达；实验研究的系统评价
Macronutrients and the FTO gene expression in hypothalamus; a systematic review of experimental studies.
作者信息
Doaei Saeid, Kalantari Naser, Mohammadi Nastaran Keshavarz, Tabesh Ghasem Azizi, Gholamalizadeh Maryam
机构信息
Student's Research Committee, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Indian Heart J. 2017 Mar-Apr;69(2):277-281. doi: 10.1016/j.ihj.2017.01.014. Epub 2017 Jan 24.
The various studies have examined the relationship between FTO gene expression and macronutrients levels. In order to obtain better viewpoint from this interactions, all of existing studies were reviewed systematically. All published papers have been obtained and reviewed using standard and sensitive keywords from databases such as CINAHL, Embase, PubMed, PsycInfo, and the Cochrane, from 1990 to 2016. The results indicated that all of 6 studies that met the inclusion criteria (from a total of 428 published article) found FTO gene expression changes at short-term follow-ups. Four of six studies found an increased FTO gene expression after calorie restriction, while two of them indicated decreased FTO gene expression. The effect of protein, carbohydrate and fat were separately assessed and suggested by all of six studies. In Conclusion, The level of FTO gene expression in hypothalamus is related to macronutrients levels. Future research should evaluate the long-term impact of dietary interventions.
各项研究探讨了FTO基因表达与常量营养素水平之间的关系。为了从这种相互作用中获得更好的观点，对所有现有研究进行了系统综述。使用CINAHL、Embase、PubMed、PsycInfo和Cochrane等数据库中1990年至2016年的标准且敏感的关键词，获取并审阅了所有已发表的论文。结果表明，符合纳入标准的6项研究（总共428篇已发表文章）均发现短期随访中FTO基因表达发生了变化。6项研究中有4项发现热量限制后FTO基因表达增加，而其中2项表明FTO基因表达降低。6项研究均分别评估并提示了蛋白质、碳水化合物和脂肪的影响。总之，下丘脑FTO基因表达水平与常量营养素水平相关。未来的研究应评估饮食干预的长期影响。
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