人T细胞对经γ干扰素治疗的同种异体小细胞肺癌的细胞溶解反应。
Cytolytic response of human T cells against allogeneic small cell lung carcinoma treated with interferon gamma.
作者信息
Weynants P, Wauters P, Coulie P G, Van den Eynde B, Symann M, Boon T
机构信息
Université Catholique de Louvain, Brussels, Belgium.
出版信息
Cancer Immunol Immunother. 1988;27(3):228-32. doi: 10.1007/BF00205444.
Abstract
Human lymphocytes stimulated in vitro by allogeneic small cell lung carcinoma cell lines did not show any significant cytolytic activity against the stimulator tumor cells. However, a high level of lysis was observed when both stimulator and target small cell lung carcinoma cells were pretreated with interferon gamma, which increased considerably the expression of major histocompatibility class I molecules by these cells. The demonstration that small cell lung carcinoma cells can be lysed by cytolytic T lymphocytes, suggests that it will be feasible to study the autologous T cell response of patients against this tumor.
摘要
体外被异基因小细胞肺癌细胞系刺激的人淋巴细胞，对刺激肿瘤细胞未表现出任何显著的细胞溶解活性。然而，当刺激细胞和靶小细胞肺癌细胞都用γ干扰素预处理时，观察到高水平的细胞溶解，这显著增加了这些细胞上主要组织相容性复合体I类分子的表达。小细胞肺癌细胞可被细胞毒性T淋巴细胞裂解，这一证明表明研究患者针对该肿瘤的自体T细胞反应将是可行的。
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