School of Medicine, Trinity College Dublin, Dublin, Ireland.
Northern Ireland Centre for Food and Health, Ulster University , Coleraine, UK.
Osteoporos Int. 2017 Aug;28(8):2409-2419. doi: 10.1007/s00198-017-4049-5. Epub 2017 May 1.
In this cohort of community dwelling older adults (>60 years), we observed significant positive associations between the frequencies of yogurt intake with measures of bone density, bone biomarkers, and indicators of physical function. Improving yogurt intakes could be a valuable health strategy for maintaining bone health in older adults.
The associations of yogurt intakes with bone health and frailty in older adults are not well documented. The aim was to investigate the association of yogurt intakes with bone mineral density (BMD), bone biomarkers, and physical function in 4310 Irish adults from the Trinity, Ulster, Department of Agriculture aging cohort study (TUDA).
Bone measures included total hip, femoral neck, and vertebral BMD with bone biochemical markers. Physical function measures included Timed Up and Go (TUG), Instrumental Activities of Daily Living Scale, and Physical Self-Maintenance Scale.
Total hip and femoral neck BMD in females were 3.1-3.9% higher among those with the highest yogurt intakes (n = 970) compared to the lowest (n = 1109; P < 0.05) as were the TUG scores (-6.7%; P = 0.013). In males, tartrate-resistant acid phosphatase (TRAP 5b) concentrations were significantly lower in those with the highest yogurt intakes (-9.5%; P < 0.0001). In females, yogurt intake was a significant positive predictor of BMD at all regions. Each unit increase in yogurt intake in females was associated with a 31% lower risk of osteopenia (OR 0.69; 95% CI 0.49-0.96; P = 0.032) and a 39% lower risk of osteoporosis (OR 0.61; 95% CI 0.42-0.89; P = 0.012) and in males, a 52% lower risk of osteoporosis (OR 0.48; 95% CI 0.24-0.96; P = 0.038).
In this cohort, higher yogurt intake was associated with increased BMD and physical function scores. These results suggest that improving yogurt intakes could be a valuable public health strategy for maintaining bone health in older adults.
本研究纳入了社区居住的老年人（>60 岁）队列，观察到酸奶摄入频率与骨密度、骨生物标志物和身体功能指标呈显著正相关。增加酸奶摄入可能是维持老年人骨骼健康的一项有价值的健康策略。
酸奶摄入与老年人的骨骼健康和虚弱之间的关联尚未得到充分证实。本研究旨在调查爱尔兰三一大学、阿尔斯特大学、农业部老龄化队列研究（TUDA）中 4310 名成年人的酸奶摄入与骨矿物质密度（BMD）、骨生物标志物和身体功能之间的关系。
骨测量包括全髋、股骨颈和椎体 BMD 以及骨生化标志物。身体功能测量包括计时起立行走测试（TUG）、工具性日常生活活动量表和身体自我维护量表。
女性中，摄入最高酸奶量（n=970）的人群全髋和股骨颈 BMD 比摄入最低酸奶量（n=1109）的人群分别高出 3.1%-3.9%（P<0.05），TUG 评分也降低了 6.7%（P=0.013）。在男性中，摄入最高酸奶量的人群中，抗酒石酸酸性磷酸酶 5b（TRAP 5b）浓度显著降低（-9.5%；P<0.0001）。在女性中，酸奶摄入是各部位 BMD 的显著正预测因子。女性中酸奶摄入量每增加一个单位，骨质疏松症的风险降低 31%（OR 0.69；95%CI 0.49-0.96；P=0.032），骨质减少症的风险降低 39%（OR 0.61；95%CI 0.42-0.89；P=0.012），男性骨质疏松症的风险降低 52%（OR 0.48；95%CI 0.24-0.96；P=0.038）。
在本队列中，较高的酸奶摄入与 BMD 和身体功能评分的增加有关。这些结果表明，增加酸奶摄入可能是维持老年人骨骼健康的一项有价值的公共卫生策略。
