Scholes Natalie S, Isalan Mark
Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Curr Opin Chem Biol. 2017 Oct;40:1-7. doi: 10.1016/j.cbpa.2017.04.008. Epub 2017 May 2.
The spatial organisation of gene expression is essential to create structure and function in multicellular organisms during developmental processes. Such organisation occurs by the execution of algorithmic functions, leading to patterns within a given domain, such as a tissue. Engineering these processes has become increasingly important because bioengineers are seeking to develop tissues ex vivo. Moreover, although there are several theories on how pattern formation can occur in vivo, the biological relevance and biotechnological potential of each of these remains unclear. In this review, we will briefly explain four of the major theories of pattern formation in the light of recent work. We will explore why programming of such patterns is necessary, while discussing a three-step framework for artificial engineering approaches.
基因表达的空间组织对于多细胞生物体在发育过程中形成结构和功能至关重要。这种组织通过算法功能的执行而发生，从而在给定的区域（如组织）内形成模式。对这些过程进行工程化处理变得越来越重要，因为生物工程师们正试图在体外培育组织。此外，尽管关于体内模式形成的方式有几种理论，但每种理论的生物学相关性和生物技术潜力仍不明确。在这篇综述中，我们将根据最近的研究工作简要解释四种主要的模式形成理论。我们将探讨为何对这些模式进行编程是必要的，同时讨论人工工程方法的三步框架。
