Oriyama Toyohito, Yamamoto Takehito, Yanagihara Yoshitsugu, Nara Katsuhiko, Abe Toshihide, Nakajima Katsuyoshi, Aoyama Takao, Suzuki Hiroshi
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan.
Tokyo University of Science, Faculty of Pharmaceutical Sciences, 2641 Yamazaki, Noda, Chiba 278-8510 Japan.
J Pharm Health Care Sci. 2017 May 2;3:13. doi: 10.1186/s40780-017-0082-y. eCollection 2017.
Medical gloves are an important piece of personal protective equipment that prevents exposure to antineoplastic agents. The permeability of medical gloves to antineoplastic agents is a crucial factor in the appropriate selection of gloves. However, the relationship between glove permeability and material type, thickness, and surface treatment is poorly understood.
A continuous flow in-line cell device was used for the evaluation of the permeation of five antineoplastic agents (etoposide, cyclophosphamide, doxorubicin hydrochloride, paclitaxel, and fluorouracil) through medical gloves. Medical gloves made of three types of materials (chlorinated latex, non-chlorinated latex, and nitrile) were subjected to a permeability test. The antineoplastic agents in test solutions were tested at the highest concentrations employed in general clinical practice. Then, the relationship between glove thickness and permeability was assessed using chlorinated latex gloves with thicknesses of 0.1, 0.15, 0.2, and 0.1 mm × 2 (to represent the practice of "double gloving").
Only cyclophosphamide and fluorouracil showed detectable permeation through the tested latex gloves. The permeability of chlorinated latex was lower than that of non-chlorinated latex. Nitrile gloves showed no detectable permeability to any of the five antineoplastic agents tested. The permeability of chlorinated latex gloves depended on the thickness of the gloves; 0.1 mm × 2 (double gloving) exhibited the highest resistance to permeation by antineoplastic agents.
The permeability of medical gloves was dependent on the type of material and the surface treatment and decreased as the thickness of the glove increased. The double glove was shown to prevent antineoplastic agent permeation more efficiently than did a single glove of the same total thickness. These results provided important information that will guide the appropriate selection of medical gloves.
医用手套是防止接触抗肿瘤药物的重要个人防护装备。医用手套对抗肿瘤药物的渗透性是手套恰当选择的关键因素。然而，手套渗透性与材料类型、厚度及表面处理之间的关系尚不清楚。
使用连续流动在线细胞装置评估五种抗肿瘤药物（依托泊苷、环磷酰胺、盐酸多柔比星、紫杉醇和氟尿嘧啶）透过医用手套的渗透性。对三种材料（氯化乳胶、非氯化乳胶和丁腈）制成的医用手套进行渗透性测试。测试溶液中的抗肿瘤药物采用一般临床实践中使用的最高浓度。然后，使用厚度为0.1、0.15、0.2和0.1mm×2（代表“双层手套”做法）的氯化乳胶手套评估手套厚度与渗透性之间的关系。
仅环磷酰胺和氟尿嘧啶在测试的乳胶手套中显示出可检测到的渗透。氯化乳胶的渗透性低于非氯化乳胶。丁腈手套对所测试的五种抗肿瘤药物均未显示出可检测到的渗透性。氯化乳胶手套的渗透性取决于手套厚度；0.1mm×2（双层手套）对抗肿瘤药物渗透的抵抗力最强。
医用手套的渗透性取决于材料类型和表面处理，并随着手套厚度增加而降低。双层手套比相同总厚度的单层手套更能有效防止抗肿瘤药物渗透。这些结果提供了重要信息，将指导医用手套的恰当选择。
