Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University , Harbin 150040, P. R. China.
J Org Chem. 2017 May 19;82(10):5481-5486. doi: 10.1021/acs.joc.7b00640. Epub 2017 May 11.
The palladium-catalyzed intramolecular acylation of alkenyl bromides and aldehydes was developed for an efficient synthesis of 4H-chromen-4-ones. With Pd(PPh)/Xphos as the catalyst and KCO as the base, this protocol was applied to synthesize a small library of diversely functionalized flavonoids in moderate to good yields in 1,4-dioxane.
钯催化的烯基溴化物和醛的分子内酰化反应被开发用于高效合成 4H-色烯-4-酮。使用 Pd(PPh)/Xphos 作为催化剂和 KCO 作为碱，该方法在 1,4-二氧六环中以中等至良好的收率合成了一系列具有不同官能团的黄酮类化合物的小文库。
