Xu Qin-Lan, Xiao Yong-Sheng, Shen Ye, Wu Hui-Min, Zhang Xuan, Deng Xin-Zhao, Wang Ting-Ting, Li Wei, Tan Ren-Xiang, Jiao Rui-Hua, Ge Hui-Ming
a State Key Laboratory of Pharmaceutical Biotechnology , Institute of Functional Biomolecules, Nanjing University , Nanjing 210046 , China.
J Asian Nat Prod Res. 2018 Mar;20(3):234-241. doi: 10.1080/10286020.2017.1320548. Epub 2017 May 8.
Chaetospirolactone (1), a novel spiro-lactone bearing a rare 1-oxaspiro [4.4] non-7-ene-2,6-dione skeleton, and orsellide F (2), together with six known compounds (3-8), were isolated from an endophytic fungus Chaetomium sp. NF00754. Their structures were determined by interpretation of spectroscopic data. The absolute configurations of 1 and 2 were established by analysis of single X-ray crystallographic data and CD spectra. Compounds 3, 4, and 6 showed moderate acetylcholinesterase inhibitory activity with IC values of 7.34, 5.19, and 7.67 μM, respectively.
Chaetospirolactone（1）是一种带有罕见的1-氧杂螺[4.4]壬-7-烯-2,6-二酮骨架的新型螺内酯，以及苔色酸F（2），与六种已知化合物（3-8）一起，从内生真菌Chaetomium sp. NF00754中分离得到。通过光谱数据的解析确定了它们的结构。通过对单晶X射线晶体学数据和圆二色光谱的分析确定了1和2的绝对构型。化合物3、4和6表现出中等程度的乙酰胆碱酯酶抑制活性，IC值分别为7.34、5.19和7.67 μM。
