Meystre S M, Lovis C, Bürkle T, Tognola G, Budrionis A, Lehmann C U
Yearb Med Inform. 2017 Aug;26(1):38-52. doi: 10.15265/IY-2017-007. Epub 2017 Sep 11.
To perform a review of recent research in clinical data reuse or secondary use, and envision future advances in this field. The review is based on a large literature search in MEDLINE (through PubMed), conference proceedings, and the ACM Digital Library, focusing only on research published between 2005 and early 2016. Each selected publication was reviewed by the authors, and a structured analysis and summarization of its content was developed. The initial search produced 359 publications, reduced after a manual examination of abstracts and full publications. The following aspects of clinical data reuse are discussed: motivations and challenges, privacy and ethical concerns, data integration and interoperability, data models and terminologies, unstructured data reuse, structured data mining, clinical practice and research integration, and examples of clinical data reuse (quality measurement and learning healthcare systems). Reuse of clinical data is a fast-growing field recognized as essential to realize the potentials for high quality healthcare, improved healthcare management, reduced healthcare costs, population health management, and effective clinical research.
对临床数据再利用或二次利用的近期研究进行综述，并展望该领域未来的进展。该综述基于在MEDLINE（通过PubMed）、会议论文集和ACM数字图书馆中进行的大量文献检索，仅关注2005年至2016年初发表的研究。作者对每篇选定的出版物进行了评审，并对其内容进行了结构化分析和总结。初步检索产生了359篇出版物，在对摘要和全文进行人工审查后数量有所减少。讨论了临床数据再利用的以下方面：动机与挑战、隐私与伦理问题、数据整合与互操作性、数据模型与术语、非结构化数据再利用、结构化数据挖掘、临床实践与研究整合以及临床数据再利用的实例（质量评估和学习型医疗系统）。临床数据的再利用是一个快速发展的领域，被认为对于实现高质量医疗、改善医疗管理、降低医疗成本、人群健康管理和有效的临床研究的潜力至关重要。
