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Immunosuppressive cell death in cancer.癌症中的免疫抑制性细胞死亡
Nat Rev Immunol. 2017 Jun;17(6):401. doi: 10.1038/nri.2017.46. Epub 2017 May 8.
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Reply: Immunosuppressive cell death in cancer.回复：癌症中的免疫抑制性细胞死亡。
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[Overseas Drug Safety Information 2008. Risk of infectious diseases associated with the use of immunosuppressive drugs].[2008年海外药品安全信息。使用免疫抑制药物相关的传染病风险]
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Plasma IFN-γ may predict pyrotinib efficacy in patients with HER2-positive advanced breast cancer.血浆干扰素-γ可能预测HER2阳性晚期乳腺癌患者的吡咯替尼疗效。
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Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade.联合铁死亡诱导与髓系来源抑制细胞（MDSC）阻断可使肝脏原发肿瘤和转移灶对免疫检查点阻断敏感。
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Delivery of an ectonucleotidase inhibitor with ROS-responsive nanoparticles overcomes adenosine-mediated cancer immunosuppression.ROS 响应型纳米颗粒递送外核苷酸酶抑制剂克服了腺苷介导的癌症免疫抑制。
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Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations.癌细胞诱导的 COX-2 上调定义了它们的炎症特性，并限制了化疗免疫治疗联合的疗效。
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本文引用的文献

1
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.通过靶向骨髓细胞中的PI3Kγ克服对检查点阻断疗法的耐药性。
Nature. 2016 Nov 17;539(7629):443-447. doi: 10.1038/nature20554. Epub 2016 Nov 9.
2
Immunogenic cell death in cancer and infectious disease.肿瘤和传染病中的免疫原性细胞死亡
Nat Rev Immunol. 2017 Feb;17(2):97-111. doi: 10.1038/nri.2016.107. Epub 2016 Oct 17.
3
Ionic immune suppression within the tumour microenvironment limits T cell effector function.肿瘤微环境中的离子免疫抑制会限制T细胞效应功能。
Nature. 2016 Sep 22;537(7621):539-543. doi: 10.1038/nature19364. Epub 2016 Sep 14.
4
Interleukin 1α and the inflammatory process.白细胞介素1α与炎症过程。
Nat Immunol. 2016 Jul 19;17(8):906-13. doi: 10.1038/ni.3503.
5
The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression.坏死小体通过CXCL1和Mincle诱导的免疫抑制促进胰腺癌发生。
Nature. 2016 Apr 14;532(7598):245-9. doi: 10.1038/nature17403. Epub 2016 Apr 6.
6
CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation.细胞周期蛋白依赖性激酶抑制剂1A（CDKN1A）在暴露于电离辐射后调节朗格汉斯细胞的存活并促进调节性T细胞的生成。
Nat Immunol. 2015 Oct;16(10):1060-8. doi: 10.1038/ni.3270. Epub 2015 Sep 7.
7
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.免疫抑制性浆细胞阻碍T细胞依赖性免疫原性化疗。
Nature. 2015 May 7;521(7550):94-8. doi: 10.1038/nature14395. Epub 2015 Apr 29.
8
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.产生白细胞介素-17的γδ T细胞和中性粒细胞共同促进乳腺癌转移。
Nature. 2015 Jun 18;522(7556):345-348. doi: 10.1038/nature14282. Epub 2015 Mar 30.
9
Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9.缺氧诱导的HMGB1与线粒体DNA相互作用通过Toll样受体9介导肝癌肿瘤生长。
J Hepatol. 2015 Jul;63(1):114-21. doi: 10.1016/j.jhep.2015.02.009. Epub 2015 Feb 12.
10
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.I 型干扰素信号在肿瘤细胞自主贡献中的作用及其对化疗疗效的影响。
Nat Med. 2014 Nov;20(11):1301-9. doi: 10.1038/nm.3708. Epub 2014 Oct 26.

Immunosuppressive cell death in cancer.

作者信息

Hou Jiajie, Greten Tim F, Xia Qiang

机构信息

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Rd, Shanghai 200127, China.

Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, Building 10, Bethesda, Maryland 20892, USA.

出版信息

Nat Rev Immunol. 2017 Jun;17(6):401. doi: 10.1038/nri.2017.46. Epub 2017 May 8.

DOI:10.1038/nri.2017.46
PMID:28480899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6309557/
Abstract
摘要