Missouri School of Dentistry and Oral Health, A.T. Still University, Kirksville, MO, 63501, USA.
Sci Eng Ethics. 2018 Apr;24(2):441-453. doi: 10.1007/s11948-017-9917-z. Epub 2017 May 8.
Interventions aiming to slow, stop, or reverse the aging process are starting to enter clinical trials. Though this line of research is nascent, it has the potential to not only prevent prolonged human suffering, but also to extend human well-being. As this line of research develops, it is important to understand the ethical constraints of conducting such research. This paper discusses some of these constraints. In particular, it discusses the ethical difficulties of conducting this research in a way that would produce reliable data regarding the effectiveness of an anti-aging intervention. Clinical trials of such interventions, I argue, will be faced with a dilemma between two confounding variables. Eliminating the variables requires introducing ethically problematic research practices. Thus, researchers must either perform research in ethically problematic ways, or forego the conduct of high-impact clinical research on anti-aging interventions.
旨在延缓、阻止或逆转衰老过程的干预措施开始进入临床试验。尽管这一研究领域还处于起步阶段,但它有可能不仅预防人类长期受苦,而且延长人类的幸福。随着这一研究领域的发展,理解进行此类研究的伦理限制非常重要。本文讨论了其中的一些限制。特别是,它讨论了在产生关于抗衰老干预措施有效性的可靠数据方面进行这项研究的伦理困难。我认为,此类干预措施的临床试验将面临两个混杂变量之间的困境。消除这些变量需要引入有伦理问题的研究实践。因此,研究人员要么以有伦理问题的方式进行研究,要么放弃进行对抗衰老干预措施有重大影响的临床研究。