Eppinga Hester, Thio H Bing, Schreurs Marco W J, Blakaj Blerdi, Tahitu Ruena I, Konstantinov Sergey R, Peppelenbosch Maikel P, Fuhler Gwenny M
Department of Dermatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
PLoS One. 2017 May 9;12(5):e0176955. doi: 10.1371/journal.pone.0176955. eCollection 2017.
Psoriasis and inflammatory bowel disease (IBD) are chronic inflammatory diseases sharing similar pathogenic pathways. Intestinal microbial changes such as a decrease of bakers' yeast Saccharomyces cerevisiae have been reported in IBD, suggesting the presence of a gut-skin axis.
To investigate whether the S. cerevisiae abundance was altered in psoriasis patients versus healthy controls, and whether dimethylfumarate (DMF) interacted with this yeast.
Using qPCR, faecal samples were compared between psoriasis patients without DMF (n = 30), psoriasis patients with DMF (n = 28), and healthy controls (n = 32).
Faecal S. cerevisiae abundance was decreased in psoriasis compared to healthy controls (p<0.001). Interestingly, DMF use raised S. cerevisiae levels (p<0.001). Gastrointestinal adverse-effects of DMF were correlated with a higher S. cerevisiae abundance (p = 0.010). In vitro, a direct effect of DMF on S. cerevisiae growth was observed. In addition, anti-Saccharomyces cerevisiae antibodies were not elevated in psoriasis.
The abundance of baker's yeast S. cerevisiae is decreased in psoriasis patients, but appears to be restored upon DMF use. S. cerevisiae is generally classified as a yeast with beneficial immunomodulatory properties, but may also be involved in the occurrence of DMF's gastrointestinal adverse-effects. Potentially, DMF might be a new therapy for IBD.
银屑病和炎症性肠病（IBD）是具有相似致病途径的慢性炎症性疾病。IBD中已报道肠道微生物变化，如面包酵母酿酒酵母数量减少，提示存在肠-皮肤轴。
研究银屑病患者与健康对照相比酿酒酵母丰度是否改变，以及富马酸二甲酯（DMF）是否与这种酵母相互作用。
采用定量聚合酶链反应（qPCR），比较未使用DMF的银屑病患者（n = 30）、使用DMF的银屑病患者（n = 28）和健康对照（n = 32）的粪便样本。
与健康对照相比，银屑病患者粪便中酿酒酵母丰度降低（p<0.001）。有趣的是，使用DMF可提高酿酒酵母水平（p<0.001）。DMF的胃肠道不良反应与较高的酿酒酵母丰度相关（p = 0.010）。在体外，观察到DMF对酿酒酵母生长有直接影响。此外，银屑病患者中抗酿酒酵母抗体未升高。
银屑病患者中面包酵母酿酒酵母的丰度降低，但使用DMF后似乎恢复。酿酒酵母通常被归类为具有有益免疫调节特性的酵母，但也可能参与DMF胃肠道不良反应的发生。DMF可能是IBD的一种新疗法。
