• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Ephrin-B2/Fc促进人脐静脉内皮细胞的增殖和迁移，并抑制其凋亡。

Ephrin-B2/Fc promotes proliferation and migration, and suppresses apoptosis in human umbilical vein endothelial cells.

作者信息

Zheng Li-Chun, Wang Xiao-Qing, Lu Kun, Deng Xiao-Ling, Zhang Cheng-Wei, Luo Hong, Xu Xu-Dong, Chen Xiao-Man, Yan Lu, Wang Yi-Qing, Shi Song-Lin

机构信息

Medical College of Xiamen University, Jinshan Community Health Service Center, Xiamen Traditional Chinese Medical Hospital, Xiamen 361000, P.R. China.

Xiamen Heart Center, Medical College of Xiamen University, Xiamen 361000, P.R. China.

出版信息

Oncotarget. 2017 Jun 20;8(25):41348-41363. doi: 10.18632/oncotarget.17298.

DOI:10.18632/oncotarget.17298
PMID:28489586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5522204/
Abstract

Tumor growth and metastasis are angiogenesis dependent. Angiogenic growth involves endothelial cell proliferation, migration, and invasion. Ephrin-B2 is a ligand for Eph receptor tyrosine kinases and is an important mediator in vascular endothelial growth factor-mediated angiogenesis. However, research offer controversial information regarding effects of ephrin-B2 on vascular endothelial cells. In this paper, proteome analyses showed that ephrin-B2/Fc significantly activates multiple signaling pathways related to cell proliferation, survival, and migration and suppresses apoptosis and cell death. Cytological experiments further confirm that ephrin-B2/Fc stimulates endothelial cell proliferation, triggers dose-dependent migration, and suppresses cell apoptosis. Results demonstrate that soluble dose-dependent ephrinB2 can promote proliferation and migration and inhibit apoptosis of human umbilical vein endothelial cells. These results also suggest that ephrinB2 prevents ischemic disease and can potentially be a new therapeutic target for treating angiogenesis-related diseases and tumors.

摘要

肿瘤生长和转移依赖于血管生成。血管生成性生长涉及内皮细胞的增殖、迁移和侵袭。Ephrin-B2是Eph受体酪氨酸激酶的配体，是血管内皮生长因子介导的血管生成中的重要介质。然而，关于ephrin-B2对血管内皮细胞的影响，研究提供了有争议的信息。在本文中，蛋白质组分析表明，ephrin-B2/Fc显著激活与细胞增殖、存活和迁移相关的多种信号通路，并抑制细胞凋亡和细胞死亡。细胞学实验进一步证实，ephrin-B2/Fc刺激内皮细胞增殖，引发剂量依赖性迁移，并抑制细胞凋亡。结果表明，可溶性剂量依赖性ephrinB2可促进人脐静脉内皮细胞的增殖和迁移，并抑制其凋亡。这些结果还表明，ephrinB2可预防缺血性疾病，并且有可能成为治疗血管生成相关疾病和肿瘤的新治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/bbf4f231b43c/oncotarget-08-41348-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/286d72c2668e/oncotarget-08-41348-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/1d246f736417/oncotarget-08-41348-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/77129a6f49e5/oncotarget-08-41348-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/e0ee75ddae26/oncotarget-08-41348-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/051cd9d2b50d/oncotarget-08-41348-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/32d74c0f48ba/oncotarget-08-41348-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/bbf4f231b43c/oncotarget-08-41348-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/286d72c2668e/oncotarget-08-41348-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/1d246f736417/oncotarget-08-41348-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/77129a6f49e5/oncotarget-08-41348-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/e0ee75ddae26/oncotarget-08-41348-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/051cd9d2b50d/oncotarget-08-41348-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/32d74c0f48ba/oncotarget-08-41348-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e7/5522204/bbf4f231b43c/oncotarget-08-41348-g007.jpg

相似文献

1
Ephrin-B2/Fc promotes proliferation and migration, and suppresses apoptosis in human umbilical vein endothelial cells.Ephrin-B2/Fc促进人脐静脉内皮细胞的增殖和迁移，并抑制其凋亡。
Oncotarget. 2017 Jun 20;8(25):41348-41363. doi: 10.18632/oncotarget.17298.
2
Eph-B2/ephrin-B2 interaction plays a major role in the adhesion and proliferation of Waldenstrom's macroglobulinemia.Eph-B2/ephrin-B2 相互作用在 Waldenstrom 巨球蛋白血症的黏附和增殖中起主要作用。
Clin Cancer Res. 2012 Jan 1;18(1):91-104. doi: 10.1158/1078-0432.CCR-11-0111. Epub 2011 Oct 18.
3
Ephrin type-B receptor 4 activation reduces neointimal hyperplasia in human saphenous vein in vitro.Ephrin B4型受体激活可在体外减少人隐静脉新生内膜增生。
J Vasc Surg. 2016 Mar;63(3):795-804. doi: 10.1016/j.jvs.2014.09.036. Epub 2014 Oct 24.
4
Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells.内皮细胞中正向EphB4信号传导控制细胞排斥以及与ephrinB2阳性细胞的分离。
J Cell Sci. 2003 Jun 15;116(Pt 12):2461-70. doi: 10.1242/jcs.00426. Epub 2003 May 6.
5
Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol-3 kinase pathway and promotes angiogenesis in adult vasculature.Ephrin-B2通过磷脂酰肌醇-3激酶途径诱导内皮细胞迁移，并促进成年血管系统中的血管生成。
Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2008-14. doi: 10.1161/01.ATV.0000096655.56262.56. Epub 2003 Sep 18.
6
Ephrin-B2 inhibits Aβ-induced apoptosis by alleviating endoplasmic reticulum stress and promoting autophagy in HT22 cells.Ephrin-B2 通过减轻内质网应激和促进自噬来抑制 Aβ 诱导的 HT22 细胞凋亡。
Neurosci Lett. 2019 Jun 21;704:50-56. doi: 10.1016/j.neulet.2019.03.028. Epub 2019 Mar 30.
7
Modulation of ephrinB2 leads to increased angiogenesis in ischemic myocardium and endothelial cell proliferation.EphrinB2的调节导致缺血心肌中血管生成增加以及内皮细胞增殖。
Biochem Biophys Res Commun. 2008 Aug 29;373(3):355-9. doi: 10.1016/j.bbrc.2008.06.036. Epub 2008 Jun 20.
8
Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth.肿瘤细胞上的EphB4与血管内皮素B2之间的相互作用调节肿瘤生长。
Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5583-8. doi: 10.1073/pnas.0401381101. Epub 2004 Apr 5.
9
Syntenin promotes VEGF-induced VEGFR2 endocytosis and angiogenesis by increasing ephrin-B2 function in endothelial cells.Syntenin通过增强内皮细胞中ephrin-B2的功能来促进VEGF诱导的VEGFR2内吞作用和血管生成。
Oncotarget. 2017 Jun 13;8(24):38886-38901. doi: 10.18632/oncotarget.16452.
10
Role of ephrin B2 in human retinal endothelial cell proliferation and migration.Ephrin B2在人视网膜内皮细胞增殖和迁移中的作用。
Cell Signal. 2003 Nov;15(11):1011-7. doi: 10.1016/s0898-6568(03)00072-x.

引用本文的文献

1
CeiTEA: Adaptive Hierarchy of Single Cells with Topological Entropy.CeiTEA：具有拓扑熵的单细胞自适应层次结构
Adv Sci (Weinh). 2025 Apr 17:e2503539. doi: 10.1002/advs.202503539.
2
Recent advances of the Ephrin and Eph family in cardiovascular development and pathologies.Ephrin和Eph家族在心血管发育及病变方面的最新进展。
iScience. 2024 Jul 19;27(8):110556. doi: 10.1016/j.isci.2024.110556. eCollection 2024 Aug 16.
3
Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branching.

本文引用的文献

1
Ephrin-B2 overexpression predicts for poor prognosis and response to therapy in solid tumors.Ephrin-B2过表达预示实体瘤预后不良及对治疗的反应。
Mol Carcinog. 2017 Mar;56(3):1189-1196. doi: 10.1002/mc.22574. Epub 2016 Nov 1.
2
EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis.EPHB4激酶失活突变导致常染色体显性遗传性淋巴管相关胎儿水肿。
J Clin Invest. 2016 Aug 1;126(8):3080-8. doi: 10.1172/JCI85794. Epub 2016 Jul 11.
3
Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis.
Notch 信号通路调控 UNC5B 抑制血管内皮细胞的增殖、迁移、连接活动和视网膜丛的分支。
Sci Rep. 2024 Jun 13;14(1):13603. doi: 10.1038/s41598-024-64375-z.
4
Head-to-head comparison of relevant cell sources of small extracellular vesicles for cardiac repair: Superiority of embryonic stem cells.心脏修复中小细胞外囊泡相关细胞来源的头对头比较：胚胎干细胞更优。
J Extracell Vesicles. 2024 May;13(5):e12445. doi: 10.1002/jev2.12445.
5
Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network.斑马鱼尾部的血管损伤调节血流和峰值壁面切应力以恢复胚胎循环网络。
Front Cardiovasc Med. 2022 Mar 18;9:841101. doi: 10.3389/fcvm.2022.841101. eCollection 2022.
6
Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration.内皮细胞 Notch 信号直接调节小 GTPase RND1，以促进 Notch 抑制内皮细胞迁移。
Sci Rep. 2022 Jan 31;12(1):1655. doi: 10.1038/s41598-022-05666-1.
7
Mutations in EPHB4 cause human venous valve aplasia.EPHB4 基因突变导致人类静脉瓣膜发育不全。
JCI Insight. 2021 Sep 22;6(18):e140952. doi: 10.1172/jci.insight.140952.
8
Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells.过氧化物酶体增殖物激活受体α缺乏减弱血管平滑肌细胞凋亡并促进其迁移。
Biochem Biophys Rep. 2021 Jul 28;27:101091. doi: 10.1016/j.bbrep.2021.101091. eCollection 2021 Sep.
9
EphB4 signaling maintains the contractile phenotype of adult venous smooth muscle cells.EphB4信号通路维持成年静脉平滑肌细胞的收缩表型。
Am J Transl Res. 2020 Aug 15;12(8):4522-4531. eCollection 2020.
10
Ephs and Ephrins in Adult Endothelial Biology.Ephs 和 Ephrins 在成人血管内皮生物学中的作用。
Int J Mol Sci. 2020 Aug 6;21(16):5623. doi: 10.3390/ijms21165623.
二甲双胍通过靶向HER2/HIF-1α/VEGF分泌轴相关机制抑制肿瘤血管生成。
Oncotarget. 2015 Dec 29;6(42):44579-92. doi: 10.18632/oncotarget.6373.
4
DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53.DNA损伤诱导的ephrin-B2反向信号传导促进耐药性并驱动携带突变型p53的结直肠癌中的上皮-间质转化。
Cell Death Differ. 2016 Apr;23(4):707-22. doi: 10.1038/cdd.2015.133. Epub 2015 Oct 23.
5
EphB4 forward signalling regulates lymphatic valve development.EphB4正向信号传导调节淋巴管瓣膜发育。
Nat Commun. 2015 Apr 13;6:6625. doi: 10.1038/ncomms7625.
6
Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: implications for xenograft models of human prostate cancer.小鼠而非人类的ephrin-B2可被丝氨酸蛋白酶激肽释放酶-4有效切割：对人类前列腺癌异种移植模型的启示。
Exp Cell Res. 2015 Apr 10;333(1):136-46. doi: 10.1016/j.yexcr.2015.02.014. Epub 2015 Feb 24.
7
miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer.miR-874通过STAT3/VEGF-A途径抑制胃癌血管生成，从而发挥肿瘤抑制作用。
Oncotarget. 2015 Jan 30;6(3):1605-17. doi: 10.18632/oncotarget.2748.
8
The multifaceted activity of VEGF in angiogenesis - Implications for therapy responses.VEGF 在血管生成中的多方面活性——对治疗反应的影响。
Cytokine Growth Factor Rev. 2014 Aug;25(4):473-82. doi: 10.1016/j.cytogfr.2014.07.009. Epub 2014 Jul 23.
9
Overexpression of EphB4, EphrinB2, and epidermal growth factor receptor in papillary thyroid carcinoma: A pilot study.EphB4、EphrinB2和表皮生长因子受体在甲状腺乳头状癌中的过表达：一项初步研究。
Head Neck. 2015 Jul;37(7):964-9. doi: 10.1002/hed.23694. Epub 2014 Jun 27.
10
Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics.Fc融合蛋白与新生儿Fc受体：实现长效和更有效治疗的结构见解
Crit Rev Biotechnol. 2015 Jun;35(2):235-54. doi: 10.3109/07388551.2013.834293. Epub 2013 Oct 24.