Weschawalit Sinee, Thongthip Siriwan, Phutrakool Phanupong, Asawanonda Pravit
Department of Medicine, Division of Dermatology.
Chula Clinical Research Center.
Clin Cosmet Investig Dermatol. 2017 Apr 27;10:147-153. doi: 10.2147/CCID.S128339. eCollection 2017.
Previous studies showed that supplementation of reduced form of glutathione (GSH, 500 mg/d) has a skin-lightening efficacy in humans. This study was designed to evaluate the influences of both GSH and oxidized form (GSSG), at doses lower than 500 mg/d, on improving skin properties.
A randomized, double-blind, placebo-controlled, parallel, three-arm study was conducted. Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks. At each visit at baseline and for 12 weeks, skin features including melanin index, wrinkles, and other relevant biophysical properties were measured. Blood samples were collected for safety monitoring.
In generalized estimating equation analyses, melanin index and ultraviolet spots of all sites including face and arm when given GSH and GSSG tended to be lower than placebo. At some sites evaluated, subjects who received GSH showed a significant reduction in wrinkles compared with those taking placebo. A tendency toward increased skin elasticity was observed in GSH and GSSG compared with placebo. There were no serious adverse effects throughout the study.
We showed that oral glutathione, 250 mg/d, in both reduced and oxidized forms effectively influences skin properties. Overall, glutathione in both forms are well tolerated.
先前的研究表明，补充还原型谷胱甘肽（GSH，500毫克/天）对人体有美白功效。本研究旨在评估低于500毫克/天剂量的GSH和氧化型（GSSG）对改善皮肤特性的影响。
进行了一项随机、双盲、安慰剂对照、平行、三臂研究。健康女性受试者被平均随机分为三组，分别口服GSH（250毫克/天）、GSSG（250毫克/天）或安慰剂，为期12周。在基线期及12周的每次访视时，测量包括黑色素指数、皱纹及其他相关生物物理特性在内的皮肤特征。采集血样进行安全性监测。
在广义估计方程分析中，给予GSH和GSSG时，包括面部和手臂在内的所有部位的黑色素指数和紫外线斑点均倾向于低于安慰剂。在一些评估部位，与服用安慰剂的受试者相比，接受GSH的受试者皱纹明显减少。与安慰剂相比，GSH和GSSG组观察到皮肤弹性增加的趋势。在整个研究过程中未出现严重不良反应。
我们发现，每天口服250毫克还原型和氧化型谷胱甘肽均能有效影响皮肤特性。总体而言，两种形式的谷胱甘肽耐受性良好。
