Jin Pengcheng, Wu Xianwen, Xu Songsong, Zhang Hui, Li Yumao, Cao Zhiping, Li Hui, Wang Shouzhi
Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture, Harbin 150030, China.
Saudi J Biol Sci. 2017 May;24(4):945-949. doi: 10.1016/j.sjbs.2015.04.014. Epub 2015 Apr 30.
Previous results from genome wide association studies (GWASs) in chickens divergently selected for abdominal fat content of Northeast Agricultural University (NEAUHLF) showed that many single nucleotide polymorphism (SNP) variants were associated with abdominal fat content. Of them, six top significant SNPs at the genome level were located within , , , , and genes. Here, expression levels of these six candidate genes were investigated in abdominal fat and liver tissue between fat and lean broilers from the 14th generation population of NEAUHLF. The results showed that expression levels of , and in the abdominal fat and , , , and in the liver tissue differed significantly between the fat and lean birds, and were correlated with abdominal fat traits. The findings will provide important references for further function investigation of the six candidate genes involved in abdominal fat deposition in chickens.
先前对东北农业大学高低腹脂双向选择品系鸡（NEAUHLF）进行的全基因组关联研究（GWAS）结果表明，许多单核苷酸多态性（SNP）变体与腹脂含量相关。其中，基因组水平上六个最显著的SNP位于 、 、 、 、 和 基因内。在此，对NEAUHLF第14代群体中脂肪型和瘦肉型肉鸡的腹脂和肝脏组织中这六个候选基因的表达水平进行了研究。结果表明，脂肪型和瘦肉型鸡之间，腹脂中 、 和 的表达水平以及肝脏组织中 、 、 、 和 的表达水平存在显著差异，且与腹脂性状相关。这些发现将为进一步研究鸡腹脂沉积相关六个候选基因的功能提供重要参考。
