Antibacterial activities of the methanol extracts of , , and three other Cameroonian plants against multi-drug resistant Gram-negative bacteria.

In the last 10 years, resistance in Gram-negative bacteria has been increasing. The present study was designed to evaluate the antibacterial activities of the methanol extracts of six Cameroonian medicinal plants , , , , and against a panel of 15 multidrug resistant Gram-negative bacterial strains. The broth microdilution was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts. The preliminary phytochemical screening of the extracts was conducted according to the reference qualitative phytochemical methods. Results showed that all extracts contained compounds belonging to the classes of polyphenols and triterpenes, other classes of chemicals being selectively distributed. The best antibacterial activities were recorded with bark and root extracts of as well as with extract, with MIC values ranging from 64 to 1024 μg/mL on 93.3% of the fifteen tested bacteria. The lowest MIC value of 64 μg/mL was recorded with bark extract against EA289. Finally, the results of this study provide evidence of the antibacterial activity of the tested plants and suggest their possible use in the control of multidrug resistant phenotypes.