“活力项目”中孕期及生命早期饮食炎症潜能与儿童肥胖及心血管代谢风险的关联
Associations of prenatal and early life dietary inflammatory potential with childhood adiposity and cardiometabolic risk in Project Viva.
作者信息
Sen S, Rifas-Shiman S L, Shivappa N, Wirth M D, Hebert J R, Gold D R, Gillman M W, Oken E
机构信息
Institutions: Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
出版信息
Pediatr Obes. 2018 May;13(5):292-300. doi: 10.1111/ijpo.12221. Epub 2017 May 10.
BACKGROUND
Limited information exists regarding the association between early-life diet and cardiometabolic risk.
OBJECTIVES
Examine associations of dietary inflammatory index (DII) in pregnancy and early childhood (3-5 years) with adiposity, blood pressure and metabolic markers in mid-childhood (6-10 years).
METHODS
Among 992 mother-child pairs from Project Viva, a pre-birth cohort, we examined associations of DII scores with outcomes using multivariable linear regression adjusted for child age and sex and maternal age, BMI, education, parity, smoking, race and income.
RESULTS
Mean (SD) maternal DII in pregnancy was -2.6(1.4) units and in child DII in early childhood was 0.3(0.7). Mean mid-childhood BMI z-score was 0.40(0.98) units. In boys only, DII in early childhood was associated with higher BMIz (adjusted β = 0.16 units per unit DII, 95%CI 0.02, 0.29), waist circumference (0.93 cm; -0.07, 1.92) and skin fold thicknesses (1.12 mm; 0.01, 2.23). Dietary inflammatory index in the highest quartiles during both pregnancy and in early childhood, compared to the lowest quartiles, was associated with higher waist circumference (2.4 cm; 0.14, 4.6) in all children, and BMIz in boys (0.78 units; 0.34, 1.22). Associations with BP and metabolic markers were null.
CONCLUSIONS
A pro-inflammatory diet in pregnancy and early childhood may promote the development of adiposity.
背景
关于早期饮食与心脏代谢风险之间的关联，现有信息有限。
目的
研究孕期和幼儿期（3至5岁）的饮食炎症指数（DII）与童年中期（6至10岁）的肥胖、血压和代谢指标之间的关联。
方法
在来自“活力项目”（一个产前队列）的992对母婴中，我们使用多变量线性回归分析了DII分数与各项结果之间的关联，并对儿童年龄、性别以及母亲年龄、BMI、教育程度、产次、吸烟情况、种族和收入进行了调整。
结果
孕期母亲的平均（标准差）DII为-2.6（1.4）单位，幼儿期儿童的DII为0.3（0.7）。童年中期的平均BMI z评分是0.40（0.98）单位。仅在男孩中，幼儿期的DII与更高的BMIz相关（调整后的β值为每单位DII 0.16单位，95%置信区间为0.02，0.29）、腰围（0.93厘米；-0.07，1.92）和皮褶厚度（1.12毫米；0.01，2.23）。孕期和幼儿期处于最高四分位数的饮食炎症指数与最低四分位数相比，在所有儿童中与更高的腰围相关（2.4厘米；0.14，4.6），在男孩中与BMIz相关（0.78单位；0.34，1.22）。与血压和代谢指标的关联不显著。
结论
孕期和幼儿期的促炎饮食可能会促进肥胖的发展。
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