Shi Min, Zhang Xiao-Yu, Yu Heguo, Xiang Shi-Hao, Xu Ling, Wei Jue, Wu Qiong, Jia Rongrong, Wang Yu-Gang, Lu Xiao-Jie
Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of General Surgery, Division of Gastrointestinal Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical College and The Second People's Hospital of Huai'an, Huai'an, Jiangsu, China.
Oncotarget. 2017 Jul 4;8(27):44195-44202. doi: 10.18632/oncotarget.17409.
Hepatocellular Carcinoma (HCC) is one of the most fatal cancers, whose incidence and death rates are still rising. Here, we report the identification of long non-coding RNAs (IncRNAs) that associated with HCC progression and metabolism based on the systematically analysis of large scale RNA-seq data from HCC patients. We identified seven lncRNAs with high confidence which were highly related with prognostic of HCC. Of note, three of them had quite different expression patterns between the control samples and the patients, and their critical roles in cancer progression were validated. We proposed that DDX11-AS1 play important role during HCC oncogenesis and may serve as potential therapy target for HCC.
肝细胞癌（HCC）是最致命的癌症之一，其发病率和死亡率仍在上升。在此，我们报告基于对HCC患者大规模RNA测序数据的系统分析，鉴定出与HCC进展和代谢相关的长链非编码RNA（lncRNA）。我们高度可靠地鉴定出7种与HCC预后高度相关的lncRNA。值得注意的是，其中3种在对照样本和患者之间具有截然不同的表达模式，并且它们在癌症进展中的关键作用得到了验证。我们提出DDX11-AS1在HCC发生过程中起重要作用，可能作为HCC的潜在治疗靶点。
