Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing, 210008, Jiangsu province, China.
Sci Rep. 2017 May 11;7(1):1805. doi: 10.1038/s41598-017-01909-8.
Caloric restriction (CR) increases lifespan, retards physiological signs of aging, and delays a variety of diseases. Reduction of inflammatory response was proposed as one of the molecular mechanisms for how CR exerts beneficial effects. The present study investigated the effects of CR on postoperative pain in rats. Adult nonobese rats were divided into two dietary groups, an ad libitum fed group (AL) and a caloric restriction group (CR) that was provided with 60% of the food intake of AL rats. After 6 weeks, the effects of CR on pain behaviors and inflammation induced by plantar incision were examined. CR rats displayed significantly reduced nonevoked pain, mechanical allodynia and thermal hyperalgesia induced by incision, and showed decreased levels of pro-inflammatory cytokines in serum, peri-incisional skin tissue and ipsilateral spinal cord dorsal horn at 6 h and 24 h after incision. The analgesic efficiency of parecoxib and morphine, two agents widely used for the management of postoperative pain clinically, was reinforced by CR. Together, CR generates antinociceptive effects on postoperative incisional pain in rats, perhaps providing some improvement of QOL in patients with postoperative pain, and the beneficial effects may be attributable to the inhibition of excessive inflammation induced by surgical injury.
热量限制（CR）可延长寿命、延缓生理衰老迹象，并可延缓多种疾病的发生。减少炎症反应被认为是 CR 发挥有益作用的分子机制之一。本研究探讨了 CR 对大鼠术后疼痛的影响。成年非肥胖大鼠分为两组，即自由进食组（AL）和热量限制组（CR），后者的食物摄入量为 AL 大鼠的 60%。6 周后，观察 CR 对足底切口引起的疼痛行为和炎症的影响。CR 大鼠表现出明显减轻的无刺激疼痛、机械性痛觉过敏和热痛觉过敏，并且在切口后 6 小时和 24 小时，血清、切口周围皮肤组织和同侧脊髓背角中的促炎细胞因子水平降低。临床中广泛用于术后疼痛管理的两种药物帕瑞昔布和吗啡的镇痛效果因 CR 而增强。总之，CR 对大鼠术后切口疼痛产生镇痛作用，可能为术后疼痛患者的生活质量提供一定改善，其有益效果可能归因于对手术损伤引起的过度炎症的抑制。
