Dixit Sanjay
Cardiovascular Division, Hospital of The University of Pennsylvania, Philadelphia, PA.
J Atr Fibrillation. 2008 May 16;1(1):27. doi: 10.4022/jafib.27. eCollection 2008 May-Jun.
With expected success rates in excess of 80% for achieving long term arrhythmia control, catheter based ablation has become a popular treatment strategy in the management of patients with atrial fibrillation (AF). However, the success of AF ablation has been tempered by the occurrence of post procedure left atrial tachycardias and / or flutters, which can be seen in up to 30% of the patients. These arrhythmias are perpetuated either due to abnormalities of impulse formation (abnormal automaticity / triggered activity), or abnormalities of impulse conduction (micro / macroreentry). Regardless of the underlying mechanism, these tachycardias manifest distinct "P" or flutter waves on the surface ECG, recognition of which may facilitate their characterization / localization. However, because of the frequent overlap in the morphology of P waves, intracardiac mapping is often the only way to distinguish them apart. This is accomplished using a combination of activation, entrainment and electroanatomic mapping techniques. Tachycardias resulting from abnormalities of impulse formation and / or microreentry are characteristically focal and usually confined in and around pulmonary vein (PV) segments which have reconnected (septal aspect of right PVs and anterior aspect of left PVs). In contrast, macroreentrant tachycardias manifest a large circuit dimension involving zone(s) of slow conduction. These are most commonly seen to occur around the mitral valve but can develop in any part of the left atrium where "gaps" across prior ablation lesion sets create altered conduction. Successful ablation of focal tachycardias is usually accomplished by isolating the reconnected PV segment(s). In case of macroreentrant arrhythmias however, a more extensive ablation approach is typically required in order to achieve conduction block across isthmus of the circuit. Using these strategies, the majority of left atrial tachycardias occurring post AF ablation can be successfully cured with excellent long term results.
对于实现长期心律失常控制,导管消融的预期成功率超过80%,因此在心房颤动(AF)患者的管理中已成为一种流行的治疗策略。然而,AF消融的成功率因术后左房心动过速和/或扑动的发生而受到影响,高达30%的患者会出现这种情况。这些心律失常的持续存在要么是由于冲动形成异常(异常自律性/触发活动),要么是由于冲动传导异常(微折返/大折返)。无论潜在机制如何,这些心动过速在体表心电图上表现出独特的“P”波或扑动波,识别这些波可能有助于对其进行特征描述/定位。然而,由于P波形态经常重叠,心内标测通常是区分它们的唯一方法。这是通过激活、拖带和电解剖标测技术的组合来完成的。由冲动形成异常和/或微折返导致的心动过速通常具有局灶性,通常局限于重新连接的肺静脉(PV)段及其周围(右PV的间隔侧和左PV的前侧)。相比之下,大折返性心动过速表现为涉及缓慢传导区的大折返环。这些最常见于二尖瓣周围,但也可在左心房的任何部位发生,先前消融病灶处的“间隙”会导致传导改变。局灶性心动过速的成功消融通常通过隔离重新连接的PV段来完成。然而,对于大折返性心律失常,通常需要更广泛的消融方法,以实现跨折返环峡部的传导阻滞。使用这些策略,AF消融术后发生的大多数左房心动过速可以成功治愈,并取得优异的长期效果。