Topping R J, Jones M M
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235.
Med Hypotheses. 1988 Sep;27(1):55-7. doi: 10.1016/0306-9877(88)90084-9.
While the commercially available sodium diethyldithiocarbamate (DEDTC) has been used by several groups in the treatment of AIDS patients, chemical evidence suggests that other dithiocarbamates which are more stable at pH 7.4 might prove to be quite superior for this purpose. Of these other compounds, sodium pyrrolidinedithiocarbamate (PDTC) and sodium di-n-propyldithiocarbamate (DPDTC) which have much longer half lives at pH 7.4, are expected to exhibit similar lipophilicity to DEDTC but superior stability towards hydrolysis. They can be expected to be superior to DEDTC, especially for oral administration.
虽然市面上可买到的二乙基二硫代氨基甲酸钠（DEDTC）已被多个研究团队用于治疗艾滋病患者，但化学证据表明，其他在pH 7.4条件下更稳定的二硫代氨基甲酸盐可能在这方面表现得更为优异。在这些其他化合物中，吡咯烷二硫代氨基甲酸钠（PDTC）和二正丙基二硫代氨基甲酸钠（DPDTC）在pH 7.4时具有长得多的半衰期，预计它们与DEDTC具有相似的亲脂性，但对水解的稳定性更高。尤其是在口服给药方面，它们有望优于DEDTC。
