MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
Environ Pollut. 2017 Aug;227:606-612. doi: 10.1016/j.envpol.2017.04.035. Epub 2017 May 11.
Pyrethroids, a class of ubiquitous insecticides, have been considered as endocrine-disrupting chemicals (EDCs). Female animal studies suggested that early-life pyrethroids exposure might delay puberty onset. However, it remains unclear whether this association applies to human populations. A total of 305 girls at the ages of 9-15 years old were recruited in Hangzhou, China in this study. The concentration of the common metabolite of pyrethroids, 3-phenoxybenzoic acid (3-PBA), was analyzed in urine samples to reflect the exposure level of pyrethroids. The associations of 3-PBA with pubertal stages were evaluated using a multinomial logistic regression model. The geometric mean level of 3-PBA was 1.11 μg/L (1.42 μg/g for creatinine-adjusted concentration). There was a significant 45% reduction in odds of being in breast stage 3 (B3) per one-unit increase in the log-transformed 3-PBA levels [OR = 0.55 (95%CI: 0.31-0.98), p = 0.042]. A similar negative association was found between urinary 3-PBA levels with later onset by pubic hair stage 2 (P2) [OR = 0.56 (95%CI: 0.36-0.90), p = 0.015]. Similar negative association was also observed between urinary 3-PBA levels and pubertal onset indicated by menarche [OR = 0.51 (95%CI: 0.28-0.93), p = 0.029]. For the first time to our knowledge, this work reveals that pyrethroids exposure may increase the risk of delayed pubertal onset in girls.
拟除虫菊酯是一类无处不在的杀虫剂，被认为是内分泌干扰化学物质 (EDCs)。动物研究表明，早期接触拟除虫菊酯可能会延迟青春期的开始。然而，目前尚不清楚这种关联是否适用于人类。本研究在中国杭州招募了 305 名 9-15 岁的女孩。通过尿样分析了拟除虫菊酯的常见代谢物 3-苯氧基苯甲酸（3-PBA）的浓度，以反映拟除虫菊酯的暴露水平。使用多项逻辑回归模型评估 3-PBA 与青春期阶段的关联。3-PBA 的几何平均水平为 1.11μg/L（肌酐校正浓度为 1.42μg/g）。3-PBA 水平每增加一个对数单位，乳房 3 期（B3）的几率降低 45%[OR=0.55（95%CI：0.31-0.98），p=0.042]。在阴毛 2 期（P2）出现较晚的情况下，尿液中 3-PBA 水平与青春期开始之间也存在类似的负相关[OR=0.56（95%CI：0.36-0.90），p=0.015]。尿液中 3-PBA 水平与初潮指示的青春期开始之间也观察到类似的负相关[OR=0.51（95%CI：0.28-0.93），p=0.029]。据我们所知，这是首次揭示拟除虫菊酯暴露可能会增加女孩青春期延迟开始的风险。
