Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.
Eur J Nutr. 2018 Aug;57(5):1873-1882. doi: 10.1007/s00394-017-1470-7. Epub 2017 May 13.
The consumption of Brazil nuts has been associated with benefits to lipid metabolism and reductions in total cholesterol and LDL concentrations. They are the richest natural source of selenium which has essential functions in human physiology. Genetic polymorphisms in Selenoprotein P could impair lipid and glucose metabolisms. The aim of this work was to verify the influence of polymorphisms in genes for selenoproteins on blood lipid levels after dietary supplementation with Brazil nuts in healthy adults.
The study included 130 healthy volunteers selected at the University of São Paulo, Brazil. They were supplemented with one nut a day for 8 weeks, followed by 8 weeks without intervention. The following analyses were performed: anthropometric measurements, serum fasting glucose, lipid profile, C-reactive protein and plasma MDA levels. The volunteers were genotyped for SNPs rs1050450, rs3811699, rs1800699, rs713041, rs3877899, rs7579, rs34713741, and rs5845 in genes for selenoproteins.
The concentrations of total cholesterol and fasting glucose levels decreased after 8 weeks of supplementation (p < 0.05). Glucose levels were modulated by rs3877899 in SEPP1, with significantly lower levels observed for individuals with the GA + AA genotype (p = 0.025). In addition, rs7579 was associated with cholesterol concentrations, which were significantly lower for individuals with the GG genotype (p = 0.053).
Supplementation with one Brazil nut a day for 8 weeks reduced total cholesterol and glucose levels. Furthermore, our results suggest that rs3877899 might be associated with glucose concentrations and rs7579 with cholesterol concentrations. Therefore, the effect of genetic variations should be considered in future nutritional interventions evaluating the response to Brazil nut supplementation.
巴西坚果的消费与脂质代谢的改善以及总胆固醇和 LDL 浓度的降低有关。它是硒的最丰富的天然来源，硒在人体生理中具有重要功能。硒蛋白 P 的遗传多态性可能会损害脂质和葡萄糖代谢。这项工作的目的是验证巴西坚果饮食补充后硒蛋白基因多态性对健康成年人血脂水平的影响。
本研究纳入了 130 名在巴西圣保罗大学筛选出的健康志愿者。他们每天补充一个坚果，持续 8 周，然后不干预 8 周。进行了以下分析：人体测量学测量、血清空腹血糖、血脂谱、C 反应蛋白和血浆 MDA 水平。志愿者对硒蛋白基因的 SNPs rs1050450、rs3811699、rs1800699、rs713041、rs3877899、rs7579、rs34713741 和 rs5845 进行了基因分型。
补充 8 周后，总胆固醇浓度和空腹血糖水平降低（p<0.05）。SEPP1 中的 rs3877899 调节了血糖水平，GA+AA 基因型个体的血糖水平明显更低（p=0.025）。此外，rs7579 与胆固醇浓度相关，GG 基因型个体的胆固醇浓度明显更低（p=0.053）。
每天补充一个巴西坚果 8 周可降低总胆固醇和血糖水平。此外，我们的结果表明，rs3877899 可能与血糖浓度有关，rs7579 与胆固醇浓度有关。因此，在未来评估巴西坚果补充对营养干预反应的研究中，应考虑遗传变异的影响。
