Eleazu Chinedum, Eleazu Kate, Kalu Winner
Department of Chemistry/Biochemistry, Federal University Ndufu-Alike, IkwoAbakaliki, Nigeria.
Department of Biochemistry, Ebonyi State UniversityAbakaliki, Nigeria.
Front Pharmacol. 2017 Apr 28;8:234. doi: 10.3389/fphar.2017.00234. eCollection 2017.
The incidence of benign prostatic hyperplasia (BPH) is gradually on the increase. While conventional drugs such as the α1-adrenergic receptor antagonists and 5α-reductase inhibitors have been found to be useful in the treatment of BPH, the adverse side effects associated with their usage, have led to increased search for alternative means of managing this disease. Furthermore, although surgery has also been suggested to be a sure method, the cost and risks associated with it excludes it as a routine treatment. Dietary polyphenols have gained public interest in recent times due to their roles in the prevention of various diseases that implicate free radicals/reactive oxygen species. However, their roles in the management of BPH have not been explored. Hence, this review on their prospects in the management of BPH and their mechanisms of action. Literature search was carried out in several electronic data bases such as PubMed, Google Scholar, Medline, Agora, and Hinari from1970 to 2017 to identify the current status of knowledge on this concept. The findings from these data bases suggest that while dietary polyphenols may not replace the need for the existing therapies in the management of BPH, they hold promise in BPH management which could be explored by researchers working in this field.
良性前列腺增生（BPH）的发病率正在逐渐上升。虽然已发现诸如α1-肾上腺素能受体拮抗剂和5α-还原酶抑制剂等传统药物对BPH的治疗有用，但与它们使用相关的不良副作用，导致人们增加了对管理这种疾病的替代方法的探索。此外，虽然手术也被认为是一种可靠的方法，但其相关的成本和风险使其不能作为常规治疗方法。近年来，膳食多酚因其在预防涉及自由基/活性氧的各种疾病中的作用而受到公众关注。然而，它们在BPH管理中的作用尚未得到探索。因此，本综述探讨它们在BPH管理中的前景及其作用机制。在1970年至2017年期间，在几个电子数据库如PubMed、谷歌学术、Medline、Agora和Hinari中进行了文献检索，以确定关于这一概念的当前知识状况。这些数据库的研究结果表明，虽然膳食多酚可能无法取代BPH管理中现有疗法的需求，但它们在BPH管理方面具有前景，该领域的研究人员可以对此进行探索。
