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单纯三尖瓣修复对成人先天性心脏病患者右心室重塑的影响

Impact of Isolated Tricuspid Valve Repair on Right Ventricular Remodelling in an Adult Congenital Heart Disease Population.

作者信息

Marsico Roberto, Bruno Vito Domenico, Chivasso Pierpaolo, Baritussio Anna, Rapetto Filippo, Guida Gustavo A, Benedetto Umberto, Caputo Massimo

机构信息

School of Clinical Sciences, Bristol Heart Institute, University of Bristol, Bristol, UK.

Cardiovascular Magnetic Resonance Unit, NIHR Bristol Cardiovascular Biomedical Research Unit, Bristol Heart Institute, University of Bristol, Bristol, UK.

出版信息

Front Cardiovasc Med. 2017 Apr 28;4:21. doi: 10.3389/fcvm.2017.00021. eCollection 2017.

Abstract

BACKGROUND

Surgical repair of isolated congenital tricuspid valve (TV) disease is rare with no well-defined indication and outcomes. Moreover, the role of right ventricle (RV) in this context has not yet been investigated.

OBJECTIVES

We sought to assess the impact of congenital TV repair on cardiac remodelling and clinical-functional status and the importance of the RV function in an adult congenital heart disease (ACHD) population.

METHODS AND RESULTS

From January 2005 to December 2015, 304 patients underwent TV surgery in our centre. Of these, 27 (ACHD) patients had isolated TV repair. Patients were evaluated with preoperative and postoperative transthoracic echocardiogram. Survival rate has been investigated with a mean clinical follow-up (FU) of 3.7 ± 2.3 years, whereas the mean echocardiographic FU was 2.9 ± 1.8 years. The clinical and functional status of patients showed a statistically significant improvement after the surgical repair in terms of New York Heart Association class (66.7 vs 7.4%;  < 0.01), clinical signs of heart failure (29.6 vs 7.4%;  < 0.01), and left ventricular function (14.8 vs 7.4%;  < 0.01). The RV and right atrium diameter were significantly reduced after surgery (5.15 ± 1.21 vs 4.32 ± 1.16;  < 0.01) and (44.7 ± 16.7 vs 26.7 ± 9.2;  < 0.01), respectively. The degree of postoperative pulmonary hypertension was also significantly reduced (40.7 vs 7.4%;  < 0.01). The survival rate was 96.3% at 1 year and 93.7% at 5 years. One patient (3.7%) had early failure of the tricuspid repair requiring a reoperation.

CONCLUSION

Isolated TV repair for adult congenital disease significantly improved patients' clinical and functional status and allowed right ventricular remodelling and functional improvement.

摘要

背景

孤立性先天性三尖瓣疾病的外科修复很少见,且尚无明确的适应症和预后情况。此外,右心室在此种情况下的作用尚未得到研究。

目的

我们旨在评估先天性三尖瓣修复对心脏重塑及临床功能状态的影响,以及右心室功能在成人先天性心脏病(ACHD)人群中的重要性。

方法与结果

2005年1月至2015年12月,我们中心有304例患者接受了三尖瓣手术。其中,27例(ACHD)患者接受了孤立性三尖瓣修复。患者术前和术后均接受经胸超声心动图检查。平均临床随访3.7±2.3年以调查生存率,平均超声心动图随访2.9±1.8年。手术修复后,患者的临床和功能状态在纽约心脏协会分级(66.7%对7.4%;P<0.01)、心力衰竭临床体征(29.6%对7.4%;P<0.01)和左心室功能(14.8%对7.4%;P<0.01)方面有统计学显著改善。术后右心室和右心房直径显著减小(分别为5.15±1.21对4.32±1.16;P<0.01)和(44.7±16.7对26.7±9.2;P<0.01)。术后肺动脉高压程度也显著降低(40.7%对7.4%;P<0.01)。1年生存率为96.3%,5年生存率为93.7%。1例患者(3.7%)三尖瓣修复早期失败,需要再次手术。

结论

成人先天性疾病的孤立性三尖瓣修复显著改善了患者的临床和功能状态,并使右心室重塑和功能得到改善。

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