Haik Josef, Kornhaber Rachel, Blal Biader, Harats Moti
Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Tel Hashomer, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Adv Wound Care (New Rochelle). 2017 May 1;6(5):166-174. doi: 10.1089/wound.2016.0722.
The aim of this study was to determine the feasibility of a portable electrospinning device for the application of wound dressings. Four polymer nanofibers dressings were applied on superficial partial thickness wounds to a porcine model and compared with a traditional paraffin tulle gras dressing. The polymer nanofibrous dressings were applied using a handheld portable electrospinning device activated at a short distance from the wound. The partial thickness donor sites were evaluated on day 2, 7, and 14 when dressings were removed and tissue samples were taken for histological examination. No significant difference was detected between the different electrospun nanofibrous dressings and traditional paraffin tulle gras. Desirable characteristics of the electrospun nanofiber dressing group included nontouch technique, ease of application, adherence and reduction in wound edema and inflammation. There was no delayed wound healing or signs of infection reported in both the electrospun nanofiber and traditional tulle gras dressings. Used on partial thickness wounds, polymer electrospun nanofiber dressings provide excellent surface topography and are a nontouch, feasible, and safe method to promote wound healing with the potential to reduce wound infections. Such custom-made nanofibrous dressings have implications for the reduction of pain and trauma, number of dressing changes, scarring, and an added cost benefit. We have demonstrated that this portable handheld electrospinning device can be utilized for different formulations and materials and customized according to the characteristics of the target wound at the various stages of wound healing.
本研究的目的是确定一种用于伤口敷料的便携式静电纺丝装置的可行性。将四种聚合物纳米纤维敷料应用于猪模型的浅表部分厚度伤口，并与传统的石蜡油纱布敷料进行比较。聚合物纳米纤维敷料使用在距伤口短距离处激活的手持式便携式静电纺丝装置进行应用。在去除敷料并采集组织样本进行组织学检查的第2天、第7天和第14天，对部分厚度的供皮区进行评估。不同的电纺纳米纤维敷料与传统石蜡油纱布之间未检测到显著差异。电纺纳米纤维敷料组的理想特性包括非接触技术、易于应用、粘附性以及伤口水肿和炎症的减轻。在电纺纳米纤维敷料和传统油纱布敷料中均未报告伤口愈合延迟或感染迹象。用于部分厚度伤口时，聚合物电纺纳米纤维敷料提供了出色的表面形貌，是一种非接触、可行且安全的促进伤口愈合的方法，有可能减少伤口感染。这种定制的纳米纤维敷料对于减轻疼痛和创伤、减少换药次数、减少疤痕以及增加成本效益具有重要意义。我们已经证明，这种便携式手持式静电纺丝装置可用于不同的配方和材料，并可根据伤口愈合各个阶段目标伤口的特征进行定制。
