Li Shengke, Jiang Nan, Zhao Wenxuan, Ding Yuan-Fu, Zheng Ying, Wang Lian-Hui, Zheng Jun, Wang Ruibing
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China.
Chem Commun (Camb). 2017 May 30;53(43):5870-5873. doi: 10.1039/c7cc02466e.
We report an unprecedented, eco-friendly, in situ activatable model antibiotic, phenylalanyl-polyethylenimine (PhePEI), to potentially diminish antibiotic pollution of the environment and associated antibiotic resistance. The inactive PhePEI can be reversibly activated upon supramolecular crosslinking by cucurbit[8]uril, conferring potent antibacterial activity.
我们报告了一种前所未有的、环保的、原位可激活的模型抗生素——苯丙氨酰-聚乙烯亚胺（PhePEI），它有可能减少环境中的抗生素污染以及相关的抗生素耐药性。无活性的PhePEI在被葫芦[8]脲进行超分子交联时可被可逆激活，从而赋予强大的抗菌活性。
