[提取物名称1]和[提取物名称2]提取物、洗必泰与次氯酸钠对[目标微生物名称]的抗菌效果比较
Comparative Antimicrobial Efficacy of and Extracts, Chlorhexidine and Sodium Hypochlorite against .
作者信息
Nourzadeh Mahdieh, Amini Arezu, Fakoor Farzaneh, Raoof Maryam, Sharififar Fariba
机构信息
Iranian Center for Endodontic Research, Dental Research Center, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dental School, Zanjan University of Medical Sciences, Zanjan, Iran.
出版信息
Iran Endod J. 2017 Spring;12(2):205-210. doi: 10.22037/iej.2017.40.
INTRODUCTION
The aim of this study was to evaluate the antimicrobial effect of and methanolic extracts, chlorhexidine (CHX) and sodium hypochlorite (NaOCl) on as the predominant species isolated from infected root canals.
METHODS AND MATERIALS
One hundred twenty mandibular premolars were randomly divided into 8 groups: 12.5 mg/mL, 6.25 mg/mL 0.2% CHX, %2 CHX, 2.5% NaOCl, 5.25% NaOCl, positive and negative control group. Sampling was performed using paper points (from the root canal space lumen) and Gates-Glidden drills (from the dentinal tubules); then colony forming units (CFU) were counted and analyzed using the Kruskal-Wallis test, followed by Mann Whitney U test. The level of significance was set at 0.05.
RESULTS
All irrigants reduced more than 99% of bacteria in root canal. In the presence of and , the bacterial count in dentin were significantly more than CHX and NaOCl groups (<0.05) except 0.2% CHX in 200 µm and 400 µm depths (>0.05).
CONCLUSION
Although 5.25% NaOCl was the most effective irrigant, all agents exerted acceptable antimicrobial activity against .
引言
本研究旨在评估[两种提取物名称]甲醇提取物、洗必泰（CHX）和次氯酸钠（NaOCl）对从感染根管中分离出的[主要菌种名称]的抗菌效果。
方法与材料
120颗下颌前磨牙随机分为8组：[提取物1浓度]12.5 mg/mL、[提取物2浓度]6.25 mg/mL、0.2% CHX、[CHX另一浓度]%2 CHX、2.5% NaOCl、5.25% NaOCl、阳性和阴性对照组。使用纸尖（从根管腔）和盖茨 - 格利登钻（从牙本质小管）进行取样；然后对菌落形成单位（CFU）进行计数，并使用Kruskal - Wallis检验进行分析，随后进行Mann Whitney U检验。显著性水平设定为0.05。
结果
所有冲洗剂均使根管内细菌减少超过99%。在[两种提取物名称]存在的情况下，牙本质中的细菌计数显著高于CHX和NaOCl组（<0.05），但在200 µm和400 µm深度处0.2% CHX除外（>0.05）。
结论
尽管5.25% NaOCl是最有效的冲洗剂，但所有药剂对[主要菌种名称]均具有可接受的抗菌活性。
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