Nourzadeh Mahdieh, Amini Arezu, Fakoor Farzaneh, Asgary Saeed
Iranian Center for Endodontic Research, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Researcher, Dental School, Zanjan University of Medical Sciences, Zanjan, Iran.
Iran Endod J. 2019 Winter;14(1):18-22. doi: 10.22037/iej.v14i1.22745.
The main cause of endodontic failure is residual bacteria in the root canal system. is the predominant species isolated from infected root canals. This study aims to compare the antibacterial activity of calcium-enriched mixture (CEM) cement and Biodentine as root canal filling materials on .
Seventy extracted human single-rooted teeth were prepared and infected with for 24 h. Specimens were randomly divided into control or experimental groups; the later were filled with either CEM cement or Biodentine. Dentinal samples were collected after 7 and 30 days and transferred to test tubes. After incubation, the number of colony forming units (CFUs) were counted and analyzed using the Kruskal-Wallis test, followed by the Mann Whitney U test. The level of significance was set at 0.05.
The reduction in mean CFU level of was significantly more in the presence of CEM cement at both time intervals (<0.001). Compared to the positive control, Biodentine significantly reduced the mean CFU level only after 30 days (<0.01).
Although both biomaterials exerted antibacterial activity against , the CEM cement had more antibacterial activity than Biodentine.
根管治疗失败的主要原因是根管系统中残留的细菌。 是从感染根管中分离出的主要菌种。本研究旨在比较富钙混合物（CEM）水泥和BioDentine作为根管充填材料对 的抗菌活性。
准备70颗拔除的人类单根牙，用 感染24小时。标本随机分为对照组或实验组；后者用CEM水泥或BioDentine充填。在7天和30天后收集牙本质样本并转移到试管中。培养后，计算菌落形成单位（CFU）的数量，并使用Kruskal-Wallis检验进行分析，随后进行Mann Whitney U检验。显著性水平设定为0.05。
在两个时间间隔内，CEM水泥存在时 的平均CFU水平降低显著更多（<0.001）。与阳性对照相比，BioDentine仅在30天后显著降低了平均CFU水平（<0.01）。
虽然两种生物材料对 均具有抗菌活性，但CEM水泥比BioDentine具有更强的抗菌活性。
