Sorbonne Universites, UPMC Universite Paris 06, CNRS, College de France, Laboratoire de Chimie de la Matiere Condensee de Paris, F-75005,. France.
Laboratoire de Chimie de la Matiere Condensee de Paris, UPMC, Tour 43-44, Et. 4, 4 place Jussieu, 75252 Paris Cedex 05. France.
Curr Pharm Des. 2017;23(24):3483-3506. doi: 10.2174/1381612823666170516130515.
Tendon injury is a clinical, societal and economical issue. Moreover, tendon repair represents an important clinical challenge, partly due to the mechanical constraints that occur at the junctions with muscle and bone. Several strategies have been developed for tendon repair. In this review, we first assess the importance of tendon injuries from different sites and their causes. After a short overview of tendon three-dimensional organization, the complexity of the perfect repair quest is presented ranging from current clinical procedures to new engineering scaffolds. We then sum up tendon engineering requirements and focus on new collagen-based scaffolds, which raise promising prospects to mimic and repair tendon. In particular, we survey quantitatively a large panel of techniques to produce these scaffolds, detailing their principle and recent improvements.
肌腱损伤是一个临床、社会和经济问题。此外，肌腱修复是一个重要的临床挑战，部分原因是在与肌肉和骨骼的连接处存在机械限制。已经开发了几种肌腱修复策略。在这篇综述中，我们首先评估了不同部位肌腱损伤的重要性及其原因。在简要概述了肌腱的三维组织后，我们介绍了从当前的临床程序到新的工程支架的完美修复探索的复杂性。然后，我们总结了肌腱工程的要求，并重点介绍了新的基于胶原蛋白的支架，这些支架为模拟和修复肌腱提供了有前景的前景。特别是，我们定量调查了生产这些支架的大量技术，详细介绍了它们的原理和最新进展。
