Ryan Christina N M, Sorushanova Anna, Lomas Alex J, Mullen Anne Maria, Pandit Abhay, Zeugolis Dimitrios I
∥Teagasc Food Research Centre, Ashtown, Ireland.
Bioconjug Chem. 2015 Jul 15;26(7):1237-51. doi: 10.1021/acs.bioconjchem.5b00091. Epub 2015 May 26.
Although glycosaminoglycans constitute a minor portion of native tissues, they play a crucial role in various physiological processes, while their abnormal expression is associated with numerous pathophysiologies. Glycosaminoglycans have become increasingly prevalent in biomaterial design for tendon repair, given their low immunogenicity and their inherent capacity to stimulate the regenerative processes, while maintaining resident cell phenotype and function. Further, their incorporation into three-dimensional scaffold conformations significantly improves their mechanical properties, while reducing the formation of peritendinous adhesions. Herein, we discuss the role of glycosaminoglycans in tendon physiology and pathophysiology and the advancements achieved to date using glycosaminoglycan-functionalized scaffolds for tendon repair and regeneration. It is evidenced that glycosaminoglycan functionalization has led to many improvements in tendon tissue engineering and it is anticipated to play a pivotal role in future reparative therapies.
尽管糖胺聚糖在天然组织中只占一小部分，但它们在各种生理过程中发挥着关键作用，而其异常表达与多种病理生理状况相关。鉴于糖胺聚糖具有低免疫原性以及刺激再生过程、维持驻留细胞表型和功能的内在能力，它们在用于肌腱修复的生物材料设计中越来越普遍。此外，将它们整合到三维支架结构中可显著改善其力学性能，同时减少腱周粘连的形成。在此，我们讨论糖胺聚糖在肌腱生理和病理生理中的作用，以及迄今为止使用糖胺聚糖功能化支架进行肌腱修复和再生所取得的进展。有证据表明，糖胺聚糖功能化已在肌腱组织工程中带来了许多改进，预计其将在未来的修复治疗中发挥关键作用。
