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基于近红外七甲川菁染料的氧化铁纳米粒子用于肿瘤靶向多模态成像和光热治疗。

Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy.

机构信息

Department of Radiology, Chonnam National University Hwasun Hospital, Hwasun, 58128, South Korea.

Medical Photonics Research Center, Korea Photonics Technology Institute, Gwangju, 61007, South Korea.

出版信息

Sci Rep. 2017 May 18;7(1):2108. doi: 10.1038/s41598-017-01108-5.

DOI:10.1038/s41598-017-01108-5
PMID:28522841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5437012/
Abstract

Near-infrared fluorescent (NIRF) imaging modality holds great promise for tumor detection and offers several advantages of bioimaging, such as high tissue penetration with less background scattering. The disadvantage of NIRF bioimaging is that it has very low spatial resolution. Thus, the combination of NIRF with magnetic resonance imaging (MRI) is a good option because MRI can provide anatomical information with a higher resolution. Heptamethine cyanine dye (MHI-148) has been reported to have tumor-targeting capability which was used here as the NIRF agent. DSPE-SPION nanoparticles were synthesized by the solvent hydration method and conjugated with MHI-148 dye to form a MRI/NIRF dual imaging probe. The size and charge of the MHI-DSPE-SPION were found to be about 84 ± 6 nm and 3.7 mV by DLS & Zeta Potential analysis. In vivo MRI of the SCC7 tumor showed an enhanced accumulation of MHI-DSPE-SPION, peaking at day 1, compared to 4 hrs with the control DSPE-SPION. An in vivo photothermal tumor reduction study was done on the SCC7 tumor of BALB/c nude mice. Tumor reduction study showed complete tumor removal after 8 days. In conclusion, MHI-DSPE-SPION can be used as a cancer theranostics material because it provides MRI-optical imaging capabilities and the photothermal therapy (PTT) effect.

摘要

近红外荧光 (NIRF) 成像方式在肿瘤检测方面具有广阔的应用前景，并具有生物成像的几个优势，例如具有较高的组织穿透性和较少的背景散射。NIRF 生物成像的缺点是空间分辨率非常低。因此，将 NIRF 与磁共振成像 (MRI) 相结合是一个不错的选择，因为 MRI 可以提供更高分辨率的解剖学信息。已报道七甲川花菁染料 (MHI-148) 具有肿瘤靶向能力，本文将其用作 NIRF 试剂。通过溶剂水合法合成了 DSPE-SPION 纳米粒子，并将其与 MHI-148 染料偶联形成 MRI/NIRF 双模态成像探针。通过 DLS 和 Zeta 电位分析发现，MHI-DSPE-SPION 的大小和电荷约为 84±6nm 和 3.7mV。SCC7 肿瘤的体内 MRI 显示，与对照组 DSPE-SPION 相比，MHI-DSPE-SPION 在第 1 天达到峰值，积累量更高。在 BALB/c 裸鼠 SCC7 肿瘤上进行了体内光热肿瘤减少研究。肿瘤减少研究表明，在第 8 天可以完全去除肿瘤。总之，MHI-DSPE-SPION 可以作为一种癌症治疗材料，因为它提供了 MRI-光学成像能力和光热治疗 (PTT) 效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/d27340ae8523/41598_2017_1108_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/8f3b6206e3a4/41598_2017_1108_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/066e104f3ff4/41598_2017_1108_Fig4_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/4a0cc8b475eb/41598_2017_1108_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/31d59f51a5e0/41598_2017_1108_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/0b52a4d6708b/41598_2017_1108_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/248239eac3c9/41598_2017_1108_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/f846d436d207/41598_2017_1108_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/3ac6ae70c1d4/41598_2017_1108_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/d27340ae8523/41598_2017_1108_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/8f3b6206e3a4/41598_2017_1108_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/e4cac0c573b4/41598_2017_1108_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/44ee764b8f68/41598_2017_1108_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/066e104f3ff4/41598_2017_1108_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/f52f2b77dbde/41598_2017_1108_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/3bde3a86a5e2/41598_2017_1108_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/4a0cc8b475eb/41598_2017_1108_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/31d59f51a5e0/41598_2017_1108_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/0b52a4d6708b/41598_2017_1108_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/248239eac3c9/41598_2017_1108_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/f846d436d207/41598_2017_1108_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/3ac6ae70c1d4/41598_2017_1108_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6cf/5437012/d27340ae8523/41598_2017_1108_Fig13_HTML.jpg

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