Truppo Matthew D
Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States.
ACS Med Chem Lett. 2017 Apr 18;8(5):476-480. doi: 10.1021/acsmedchemlett.7b00114. eCollection 2017 May 11.
The use of biocatalysis in the pharmaceutical industry continues to expand as a result of increased access to enzymes and the ability to engineer those enzymes to meet the demands of industrial processes. However, we are still just scratching the surface of potential biocatalytic applications. The time pressures present in pharmaceutical process development are incompatible with the long lead times required for engineering a suitable biocatalyst. Dramatic increases in the speed of protein engineering are needed to deliver on the ever increasing opportunities for industrial biocatalytic processes.
由于获取酶的途径增加以及能够对这些酶进行改造以满足工业生产过程的需求，生物催化在制药行业的应用持续扩大。然而，我们对潜在生物催化应用的探索仍只是皮毛。制药工艺开发中的时间压力与设计合适生物催化剂所需的较长前置时间不相容。为了抓住工业生物催化过程日益增多的机会，蛋白质工程的速度需要大幅提高。
