Li Han-Min, Ye Zhi-Hua
Institute of Application Foundation and Institute of Liver Diseases, Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, 430061, China.
Hubei Province Academy of Traditional Chinese Medicine, Wuhan, 430074, China.
Chin J Integr Med. 2017 Jul;23(7):555-560. doi: 10.1007/s11655-017-2806-0. Epub 2017 May 18.
The occurrence and development of liver cancer are essentially the most serious outcomes of uncontrolled liver regeneration. The progression of liver cancer is inevitably related to the abnormal microenvironment of liver regeneration. The deterioration observed in the microenvironment of liver regeneration is a necessary condition for the occurrence, development and metastasis of cancer. Therefore, the use of a technique to prevent and treat liver cancer via changes in the microenvironment of liver regeneration is a novel strategy. This strategy would be an effective way to delay, prevent or even reverse cancer occurrence, development and metastasis through an improvement in the liver regeneration microenvironment along with the integrated regulation of multiple components, targets, levels, channels and time sequences. In addition, the treatment of "tonifying Shen (Kidney) to regulate liver regeneration and repair by affecting stem cells and their microenvironment" can regulate "the dynamic imbalance between the normal liver regeneration and the abnormal liver regeneration"; this would improve the microenvironment of liver regeneration, which is also a mechanism by which liver cancer may be prevented or treated.
肝癌的发生发展本质上是肝脏再生失控的最严重后果。肝癌的进展不可避免地与肝脏再生的异常微环境相关。肝脏再生微环境中观察到的恶化是癌症发生、发展和转移的必要条件。因此，通过改变肝脏再生微环境来防治肝癌的技术是一种新策略。该策略将是一种有效的方法，通过改善肝脏再生微环境以及对多个成分、靶点、水平、途径和时间序列的综合调控，来延缓、预防甚至逆转癌症的发生、发展和转移。此外，“补肾调肝，从干细胞及其微环境论治肝再生修复”可调控“正常肝再生与异常肝再生之间的动态失衡”；这将改善肝脏再生微环境，这也是预防或治疗肝癌的一种机制。
