非裔人群血清脂质的种族间差异及其对心血管代谢疾病风险的影响。
Interethnic Differences in Serum Lipids and Implications for Cardiometabolic Disease Risk in African Ancestry Populations.
机构信息
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Glob Heart. 2017 Jun;12(2):141-150. doi: 10.1016/j.gheart.2017.01.011. Epub 2017 May 17.
Abstract
African Americans generally have a healthier lipid profile (lower triglycerides and higher high-density lipoprotein cholesterol concentration) compared with those of other ethnicities. Paradoxically, African Americans do not experience a decreased risk of the cardiometabolic diseases that serum lipids are expected to predict. This review explores this mismatch between biomarker and disease among African ancestry individuals by investigating the presence of interethnic differences in the biological relationships underlying the serum lipids-disease association. This review also discusses the physiologic and genomic factors underlying these interethnic differences. Additionally, because of the importance of serum lipids in assessing disease risk, interethnic differences in serum lipids have implications for identifying African ancestry individuals at risk of cardiometabolic disease. Where possible, data from Africa is included, to further elucidate these ancestral differences in the context of a different environmental background.
摘要
与其他族裔相比，非裔美国人的血脂指标通常更健康（甘油三酯水平较低，高密度脂蛋白胆固醇浓度较高）。但矛盾的是，非裔美国人并没有降低患心血管代谢疾病的风险，而这些疾病正是人们期望通过血清脂质来预测的。本综述通过研究血清脂质与疾病关联背后的生物学关系中存在的种族间差异，探讨了非裔个体中生物标志物与疾病之间的这种不匹配现象。本综述还讨论了导致这些种族间差异的生理和基因组因素。此外，由于血清脂质在评估疾病风险方面的重要性，因此血清脂质的种族间差异对于识别患心血管代谢疾病风险的非裔个体具有重要意义。在可能的情况下，还纳入了来自非洲的数据，以进一步阐明在不同环境背景下的这些祖先差异。
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