Borisova L S, Kalinkovich A G, Inzhevatkina S M, Zakirov M M, Gol'dshteĭn M M
Farmakol Toksikol. 1988 Nov-Dec;51(6):65-9.
Not adhering to a plastic, B-cells of intact or immunized with the suboptimal dose of ram erythrocytes mice were treated in vitro with several agonists and antagonists of cAMP and prostaglandins E and then were transferred to syngenic or allogenic unirradiated recipients. Afterwards the number of the antibody-forming cells against ram erythrocytes was determined. It was shown that a decrease of cAMP and prostaglandin E contents in the intact B-cells results in the appearance of the ability to stimulate the immune response. An increase of cAMP content in the immune B-cells is followed by a reduction of their suppressing activity. The absence of the relationship between this activity and prostaglandin E content in the immune cells is suggested.
不附着于塑料的、来自未免疫或用次优剂量的绵羊红细胞免疫的小鼠的B细胞，在体外先用几种环磷酸腺苷（cAMP）和前列腺素E的激动剂及拮抗剂处理，然后转移至同基因或异基因未受照射的受体。之后测定针对绵羊红细胞的抗体形成细胞数量。结果表明，完整B细胞中环磷酸腺苷和前列腺素E含量的降低导致刺激免疫反应能力的出现。免疫B细胞中环磷酸腺苷含量的增加伴随着其抑制活性的降低。提示这种活性与免疫细胞中前列腺素E含量之间不存在关联。
