Mostofsky Elizabeth, Berg Johansen Martin, Tjønneland Anne, Chahal Harpreet S, Mittleman Murray A, Overvad Kim
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA.
Heart. 2017 Aug;103(15):1163-1167. doi: 10.1136/heartjnl-2016-310357. Epub 2017 May 23.
To evaluate the association between chocolate intake and incident clinically apparent atrial fibrillation or flutter (AF).
The Danish Diet, Cancer, and Health Study is a large population-based prospective cohort study. The present study is based on 55 502 participants (26 400 men and 29 102 women) aged 50-64 years who had provided information on chocolate intake at baseline. Incident cases of AF were ascertained by linkage with nationwide registries.
During a median of 13.5 years there were 3346 cases of AF. Compared with chocolate intake less than once per month, the rate of AF was lower for people consuming 1-3 servings/month (hazard ratio (HR) 0.90, 95% confidence interval (CI) 0.82 to 0.98), 1 serving/week (HR 0.83, 95% CI 0.74 to 0.92), 2-6 servings/week (HR 0.80, 95% CI 0.71 to 0.91) and ≥1 servings/day (HR 0.84, 95% CI 0.65 to 1.09; p-linear trend <0.0001), with similar results for men and women.
Accumulating evidence indicates that moderate chocolate intake may be inversely associated with AF risk, although residual confounding cannot be ruled out.
评估巧克力摄入量与临床明显的房颤或房扑（AF）发病之间的关联。
丹麦饮食、癌症与健康研究是一项基于人群的大型前瞻性队列研究。本研究基于55502名年龄在50 - 64岁之间的参与者（26400名男性和29102名女性），他们在基线时提供了巧克力摄入量信息。通过与全国登记处的关联确定房颤的发病病例。
在中位13.5年期间，有3346例房颤病例。与每月食用巧克力少于一次相比，每月食用1 - 3份巧克力的人群房颤发生率较低（风险比（HR）0.90，95%置信区间（CI）0.82至0.98），每周食用1份巧克力的人群房颤发生率较低（HR 0.83，95% CI 0.74至0.92），每周食用2 - 6份巧克力的人群房颤发生率较低（HR 0.80，95% CI 0.71至0.91），每天食用≥1份巧克力的人群房颤发生率较低（HR 0.84，95% CI 0.65至1.09；线性趋势p<0.0001），男性和女性的结果相似。
越来越多的证据表明，适量摄入巧克力可能与房颤风险呈负相关，尽管不能排除残余混杂因素。
